Emanuele Enzo, Martinelli Valentina, Abbiati Vera, Ricevuti Giovanni
Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy.
Front Biosci (Elite Ed). 2012 Jan 1;4(2):700-10. doi: 10.2741/411.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an important vascular component, ultimately resulting in dementia. Recent years have witnessed an enormous interest in the field of biomarkers in medicine both in the field of atherosclerosis and neurodegeneration. Numerous studies have recently reported altered levels of biomarkers of atherosclerotic vascular disease in patients with AD. This review provides an overview of clinical studies assessing biomarkers of atherosclerosis/vascular disease in the serum/plasma of patients with AD and highlights future directions in the field. The study of specific biomarkers of atherosclerosis in AD can contribute to identify different components of the pathophysiology and the complex mechanisms underlying the progression of the disease.
阿尔茨海默病（AD）是一种具有重要血管成分的进行性神经退行性疾病，最终导致痴呆。近年来，医学领域对动脉粥样硬化和神经退行性变领域的生物标志物产生了极大兴趣。最近有大量研究报道，AD患者动脉粥样硬化性血管疾病的生物标志物水平发生了改变。本综述概述了评估AD患者血清/血浆中动脉粥样硬化/血管疾病生物标志物的临床研究，并强调了该领域的未来发展方向。对AD中动脉粥样硬化特异性生物标志物的研究有助于识别疾病病理生理学的不同组成部分以及疾病进展背后的复杂机制。
