Chen Yu-Chang, Wu Jui-Sheng, Yang Shun-Tai, Huang Chien-Yu, Chang Chen, Sun Grace Y, Lin Teng-Nan
Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan, ROC.
Front Biosci (Schol Ed). 2012 Jan 1;4(2):599-610. doi: 10.2741/s287.
Stroke, or brain attack, is the third leading cause of death and the leading cause of adult disability worldwide. There is a great demand for intervention therapy. Unfortunately, although more than 700 drugs that target neuroprotection showed beneficial effects in preclinical animal studies, none of them proved efficacious in treating stroke patients. There is recent interest in understanding mechanism for post-ischemic angiogenesis in the penumbra area, and correlation of the extent of angiogenesis with survival in stroke patients. It is postulated that besides replenishing oxygen and nutrients to ischemic tissue, angiogenesis may play a crucial role in neural protection and tissue recovery. Consequently, therapeutic agents to promote angiogenesis and formation of new vessels after stroke can offer promising approach. Several large population epidemiological and clinical studies have revealed a reciprocal relationship between intake of phytochemicals and incidence of stroke. However, the detailed cellular and molecular mechanisms leading to these beneficial effects remain to be elucidated. In this article, we review the current knowledge on phytochemicals and post-ischemic angiogenesis, and discuss the possibility of a combinatorial treatment, including neuroprotection, angiogenesis, neurogenesis, and phytochemicals regimen for stroke.
中风，即脑卒，是全球第三大致死原因，也是成年人残疾的首要原因。对干预疗法的需求巨大。不幸的是，尽管700多种针对神经保护的药物在临床前动物研究中显示出有益效果，但没有一种药物在治疗中风患者方面被证明有效。最近人们对了解缺血半暗带区域缺血后血管生成的机制，以及血管生成程度与中风患者存活率之间的相关性产生了兴趣。据推测，除了为缺血组织补充氧气和营养物质外，血管生成可能在神经保护和组织恢复中起关键作用。因此，促进中风后血管生成和新血管形成的治疗药物可能提供有前景的方法。几项大型人群流行病学和临床研究揭示了植物化学物质的摄入与中风发病率之间的相互关系。然而，导致这些有益效果的详细细胞和分子机制仍有待阐明。在本文中，我们综述了关于植物化学物质和缺血后血管生成的当前知识，并讨论了联合治疗的可能性，包括用于中风的神经保护、血管生成、神经发生和植物化学物质疗法。
