Ma Xiaoyu, Wang Juejin
The Second Clinical Medical School, Nanjing Medical University, Nanjing, China.
Department of Physiology, Nanjing Medical University, Nanjing, China.
Front Integr Neurosci. 2022 Jul 13;16:908378. doi: 10.3389/fnint.2022.908378. eCollection 2022.
Formononetin (FMN) is a phytoestrogen member of the flavonoid family, which has the pharmacological effects of antioxidative, antihypertensive, antitumor, and anti-infective. FMN demonstrates potential in the prevention and treatment of diseases, specifically neurological diseases, such as traumatic brain injury (TBI), spinal cord injury (SCI), ischemic stroke, cerebral ischemia-reperfusion, Alzheimer's disease, and nerve tumor. Herein, a literature search is conducted to provide information on the signaling pathways of neuroprotection of formononetin based on the neuroprotective study. The significant neuroprotective function of FMN makes it a novel candidate for the development of drugs targeting the central nervous system.
大豆苷元（FMN）是黄酮类家族中的一种植物雌激素，具有抗氧化、抗高血压、抗肿瘤和抗感染等药理作用。FMN在疾病的预防和治疗中显示出潜力，特别是在神经疾病方面，如创伤性脑损伤（TBI）、脊髓损伤（SCI）、缺血性中风、脑缺血再灌注、阿尔茨海默病和神经肿瘤。在此，基于神经保护研究进行文献检索，以提供有关大豆苷元神经保护信号通路的信息。FMN显著的神经保护功能使其成为开发中枢神经系统靶向药物的新型候选物。
