Kallio M
Department of Neurology, University of Helsinki, Finland.
Acta Neurol Scand. 1990 Jun;81(6):541-9. doi: 10.1111/j.1600-0404.1990.tb01016.x.
During the 3 years 1978-1980 146 adult patients with intracranial glioma were diagnosed in the Province of Uusimaa in southern Finland. The median survival of all patients was 15 months, of glioblastoma (n = 41) 5.1 months, of anaplastic astrocytoma (n = 29) 12.4 months, of benign grade I-II astrocytoma (n = 30) 93.5 months, of other glioma 82.9 months (n = 27), and of probable glioma 9.8 months (n = 19); 22 patients are still alive 8.9-11.9 years after diagnosis. The patients who were 15-44 years of age at the time of diagnosis survived 75.4 months in the median (n = 58), 45-64 years 10.5 months (n = 61) and 65 years or older 4.8 months (n = 27); 96 patients were operated, 89 received radiotherapy and 34 chemotherapy. According to the proportional hazards' model, follow-up time, age and histological type of tumor were statistically highly significant in explaining differences in survival.
1978年至1980年的3年间，芬兰南部的新地区有146例成年颅内胶质瘤患者被确诊。所有患者的中位生存期为15个月，胶质母细胞瘤（n = 41）为5.1个月，间变性星形细胞瘤（n = 29）为12.4个月，I-II级良性星形细胞瘤（n = 30）为93.5个月，其他胶质瘤（n = 27）为82.9个月，疑似胶质瘤（n = 19）为9.8个月；22例患者在诊断后8.9至11.9年仍存活。诊断时年龄在15至44岁的患者中位生存期为75.4个月（n = 58），45至64岁为10.5个月（n = 61），65岁及以上为4.8个月（n = 27）；96例患者接受了手术，89例接受了放疗，34例接受了化疗。根据比例风险模型，随访时间、年龄和肿瘤组织学类型在解释生存差异方面具有高度统计学意义。
