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蛛网膜下腔出血患者脑脊液中内皮素浓度升高。

Increased endothelin concentration in CSF from patients with subarachnoid hemorrhage.

作者信息

Suzuki H, Sato S, Suzuki Y, Takekoshi K, Ishihara N, Shimoda S

机构信息

Department of Endocrinology, Dokkyo University School of Medicine, Mibu, Japan.

出版信息

Acta Neurol Scand. 1990 Jun;81(6):553-4. doi: 10.1111/j.1600-0404.1990.tb01018.x.

DOI:10.1111/j.1600-0404.1990.tb01018.x
PMID:2220315
Abstract

A considerable quantity of endothelin-like immunoreactivity was demonstrated as present in the CSF of patients with subarachnoid hemorrhage. The endothelin levels in the CSF raised from 0.4 +/- 0.2 (Mean +/- SD) pmol/L at Day 0-1 to 2.2 +/- 0.6 pmol/L at Day 6 and the levels decreased gradually. The result suggest that endothelin may contribute the generation of vasospasm often observed in subarachnoid hemorrhage.

摘要

大量内皮素样免疫反应物质在蛛网膜下腔出血患者的脑脊液中被证实存在。脑脊液中的内皮素水平从第0 - 1天的0.4±0.2（平均值±标准差）pmol/L升高至第6天的2.2±0.6 pmol/L，且随后水平逐渐下降。结果表明内皮素可能与蛛网膜下腔出血中常见的血管痉挛的发生有关。

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