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由泊沙康唑引起的医源性库欣综合征。

Iatrogenic Cushing's syndrome induced by posaconazole.

机构信息

Service de Maladies Infectieuses et Tropicales, Groupe Hospitalier Necker-Enfants Malades, Centre d'Infectiologie Necker-Pasteur, Paris, France.

出版信息

Antimicrob Agents Chemother. 2013 Nov;57(11):5727-8. doi: 10.1128/AAC.00416-13. Epub 2013 Aug 26.

DOI:10.1128/AAC.00416-13
PMID:23979730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3811248/
Abstract

Iatrogenic Cushing's syndrome is an undesirable outcome of glucocorticoids treatment. It can be increased by pharmacologic interactions. Glucocorticoid therapy, given in association with ritonavir, and some azole treatments are causes of iatrogenic Cushing's syndrome. We present a patient with common-variable immunodeficiency who received 7 years of itraconazole therapy for bronchial colonization with Aspergillus in combination with inhaled fluticasone without any Cushingoid symptoms. After a switch to posaconazole, the patient developed Cushingoid symptoms.

摘要

医源性库欣综合征是糖皮质激素治疗的不良后果。它可以通过药物相互作用而增加。与利托那韦和一些唑类药物联合治疗的糖皮质激素治疗是医源性库欣综合征的原因。我们报告了 1 例患有普通可变免疫缺陷的患者，该患者因支气管曲霉菌定植而接受了 7 年的伊曲康唑治疗，同时吸入氟替卡松，没有出现库欣样症状。改用泊沙康唑后，患者出现了库欣样症状。

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本文引用的文献

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Iatrogenic Cushing syndrome due to nasal steroid drops.因鼻用类固醇滴液导致的医源性库欣综合征。
Eur J Pediatr. 2012 Apr;171(4):735-6. doi: 10.1007/s00431-011-1645-9. Epub 2011 Dec 28.
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Rapid onset of iatrogenic adrenal insufficiency in a patient with cystic fibrosis-related liver disease treated with inhaled corticosteroids and a moderate CYP3A4 inhibitor.一位患有囊性纤维化相关肝病的患者在接受吸入皮质类固醇和中等 CYP3A4 抑制剂治疗后出现医源性肾上腺功能不全。
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Efficacy and safety of posaconazole for chronic pulmonary aspergillosis.泊沙康唑治疗慢性肺部曲霉病的疗效和安全性。
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Adrenal suppression and Cushing's syndrome secondary to an interaction between ritonavir and fluticasone: a review of the literature.利托那韦与氟替卡松相互作用继发的肾上腺抑制和库欣综合征：文献综述
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Ritonavir-fluticasone interaction causing Cushing syndrome in HIV-infected children and adolescents.利托那韦-氟替卡松相互作用导致HIV感染儿童和青少年出现库欣综合征。
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Comparison of epidemiological, clinical, and biological features of invasive aspergillosis in neutropenic and nonneutropenic patients: a 6-year survey.中性粒细胞减少和非中性粒细胞减少患者侵袭性曲霉病的流行病学、临床和生物学特征比较：一项为期6年的调查。
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