由泊沙康唑引起的医源性库欣综合征。
Iatrogenic Cushing's syndrome induced by posaconazole.
机构信息
Service de Maladies Infectieuses et Tropicales, Groupe Hospitalier Necker-Enfants Malades, Centre d'Infectiologie Necker-Pasteur, Paris, France.
出版信息
Antimicrob Agents Chemother. 2013 Nov;57(11):5727-8. doi: 10.1128/AAC.00416-13. Epub 2013 Aug 26.
Abstract
Iatrogenic Cushing's syndrome is an undesirable outcome of glucocorticoids treatment. It can be increased by pharmacologic interactions. Glucocorticoid therapy, given in association with ritonavir, and some azole treatments are causes of iatrogenic Cushing's syndrome. We present a patient with common-variable immunodeficiency who received 7 years of itraconazole therapy for bronchial colonization with Aspergillus in combination with inhaled fluticasone without any Cushingoid symptoms. After a switch to posaconazole, the patient developed Cushingoid symptoms.
摘要
医源性库欣综合征是糖皮质激素治疗的不良后果。它可以通过药物相互作用而增加。与利托那韦和一些唑类药物联合治疗的糖皮质激素治疗是医源性库欣综合征的原因。我们报告了 1 例患有普通可变免疫缺陷的患者，该患者因支气管曲霉菌定植而接受了 7 年的伊曲康唑治疗，同时吸入氟替卡松，没有出现库欣样症状。改用泊沙康唑后，患者出现了库欣样症状。
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2
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