Departments of Imaging and Medicine, and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
J Nucl Cardiol. 2012 Apr;19(2):265-76. doi: 10.1007/s12350-011-9496-3. Epub 2011 Dec 28.
We aimed to characterize normal limits and to determine the diagnostic accuracy for an automated quantification of 3D 82-Rubidium (Rb-82) PET/CT myocardial perfusion imaging (MPI).
We studied 125 consecutive patients undergoing Rb-82 PET/CT MPI, including patients with suspected coronary artery disease (CAD) and invasive coronary angiography, and 42 patients with a low likelihood (LLk) of CAD. Normal limits for perfusion and function were derived from LLk patients. QPET software was used to quantify perfusion abnormality at rest and stress expressed as total perfusion deficit (TPD).
Relative perfusion databases did not differ in any of the 17 segments between males and females. The areas under the receiver operating characteristic curve for detection of CAD were 0.86 for identification of ≥50% and ≥70% stenosis. The sensitivity/specificity was 86%/86% for detecting ≥50% stenosis and 93%/77% for ≥70% stenosis, respectively. In regard to normal limits, mean rest and stress left ventricular ejection fraction (LVEF) were 67% ± 10% and 75% ± 9%, respectively. Mean transient ischemic dilation ratio was 1.06 ± 0.14 and mean increase in LVEF with stress was 7.4% ± 6.1% (95th percentile of 0%).
Normal limits have been established for 3D Rb-82 PET/CT analysis with QPET software. Fully automated quantification of myocardial perfusion PET data shows high diagnostic accuracy for detecting obstructive CAD.
我们旨在描述正常范围，并确定 3D 82-铷（Rb-82）PET/CT 心肌灌注成像（MPI）自动定量的诊断准确性。
我们研究了 125 例连续接受 Rb-82 PET/CT MPI 的患者，包括疑似冠心病（CAD）和有创冠状动脉造影的患者，以及 42 例 CAD 可能性低（LLk）的患者。从 LLk 患者中得出灌注和功能的正常范围。使用 QPET 软件定量静息和应激时的灌注异常，表现为总灌注缺损（TPD）。
在男性和女性的 17 个节段中，相对灌注数据库在任何一个节段都没有差异。用于检测 CAD 的 ROC 曲线下面积分别为识别 ≥50%和≥70%狭窄的 0.86。检测 ≥50%狭窄的敏感性/特异性分别为 86%/86%，检测≥70%狭窄的敏感性/特异性分别为 93%/77%。关于正常范围，左心室射血分数（LVEF）的平均静息和应激值分别为 67%±10%和 75%±9%。平均短暂性缺血扩张比为 1.06±0.14，应激时 LVEF 的平均增加量为 7.4%±6.1%（95%置信区间为 0%）。
已经为 QPET 软件的 3D Rb-82 PET/CT 分析建立了正常范围。心肌灌注 PET 数据的全自动定量显示出对检测阻塞性 CAD 的高诊断准确性。
