Kitayama S, Nakano R
Department of Obstetrics and Gynecology, Wakayama Medical College, Japan.
Acta Obstet Gynecol Scand. 1990;69(3):245-8. doi: 10.3109/00016349009028688.
Estradiol (E2) and progesterone (P4) levels in peripheral venous blood were measured in 45 postmenopausal (more than 5 years after menopause) women with ovarian neoplasms. The E2 and P4 concentrations in ovarian venous blood were also measured in 26 of these 45 patients. The steroid levels were compared with the values in 10 postmenopausal women without ovarian tumors. In peripheral venous blood, relatively high E2 concentrations were found in 24 of the 45 (53%) postmenopausal patients with ovarian tumors, and relatively high P4 concentrations were noted 15 of 45 (33%) of the patients. In ovarian venous blood, relatively high values of E2 were found in 18 of 26 (69%) of the postmenopausal patients, and relatively high values of P4 were noted in 11 of these 26 (42%). No differences in the E2 and P4 levels in peripheral and ovarian venous blood were noted between the patients with benign tumors and those with malignant tumors. These results suggest that some of the epithelial ovarian tumors in postmenopausal women have steroid-producing activity.
对45例绝经后（绝经超过5年）卵巢肿瘤女性的外周静脉血中的雌二醇（E2）和孕酮（P4）水平进行了测定。在这45例患者中的26例还测定了卵巢静脉血中的E2和P4浓度。将这些类固醇水平与10例无卵巢肿瘤的绝经后女性的值进行了比较。在外周静脉血中，45例绝经后卵巢肿瘤患者中有24例（53%）的E2浓度相对较高，45例患者中有15例（33%）的P4浓度相对较高。在卵巢静脉血中，26例绝经后患者中有18例（69%）的E2值相对较高，这26例中有11例（42%）的P4值相对较高。良性肿瘤患者和恶性肿瘤患者在外周和卵巢静脉血中的E2和P4水平没有差异。这些结果表明，绝经后女性的一些上皮性卵巢肿瘤具有产生类固醇的活性。
