Departament de Tecnología Química i de Tensioactius, Institut de Química Avançada de Catalunya (IQAC), Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain.
Colloids Surf B Biointerfaces. 2012 Apr 1;92:322-6. doi: 10.1016/j.colsurfb.2011.12.005. Epub 2011 Dec 14.
The presented work evaluates the use of bicellar systems as new delivery vectors for controlled release of compounds through the skin. Two different active principles were introduced into the bicellar systems: diclofenac diethylamine (DDEA) and flufenamic acid (Ffa). Bicellar systems are discoidal aggregates formed by long and short alkyl chain phospholipids. Characterization of the bicellar systems by dynamic light scattering (DLS) and cryogenic transmission electron microscopy (Cryo-TEM) showed that particle size decreased when DDEA was encapsulated and increased when Ffa was included in the bicellar systems. Percutaneous absorption studies demonstrated a lower penetration of DDEA and Ffa through the skin when the drugs were included in the bicellar systems than when the drugs were applied in an aqueous solution (DDEA) and in an ethanolic solution (Ffa); the reduction in penetration was more pronounced with Ffa. These bicellar systems may have retardant effects on percutaneous absorption, which result in a promising strategy for future drug or cosmetic delivery applications.
本工作评估了双分子胶束系统作为通过皮肤控制释放化合物的新型传递载体的用途。两种不同的活性物质被引入双分子胶束系统中：双氯芬酸钠二乙胺（DDEA）和氟芬那酸（Ffa）。双分子胶束系统是由长链和短链烷基磷脂形成的圆盘状聚集体。通过动态光散射（DLS）和低温透射电子显微镜（Cryo-TEM）对双分子胶束系统进行的表征表明，当 DDEA 被包裹时，粒径减小，而当 Ffa 包含在双分子胶束系统中时，粒径增加。经皮吸收研究表明，当药物包含在双分子胶束系统中时，DDEA 和 Ffa 通过皮肤的渗透速度低于药物在水溶液（DDEA）和乙醇溶液（Ffa）中的渗透速度；Ffa 的渗透减少更为明显。这些双分子胶束系统可能对经皮吸收具有延迟作用，这为未来药物或化妆品传递应用提供了有前途的策略。
