Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, UMC St. Radboud, Nijmegen, The Netherlands.
Neurosci Biobehav Rev. 2012 Feb;36(2):786-98. doi: 10.1016/j.neubiorev.2011.12.009. Epub 2011 Dec 23.
Serotonin (5-HT) is an ancient molecule directing behavioural responses to environmental stimuli. The social environment is the most powerful environmental factor. It is well recognized that 5-HT plays a key role in shaping social responses, and that the serotonergic system itself is highly responsive to social influences. This review aims to provide an overview of a selection of representative papers that significantly contribute to a coherent view on the role of serotonin in reciprocal social interactions. The studies here reviewed, selected using the pubmed search terms "social behaviour" and "serotonin", describe the effects of serotonergic gene variation and pharmacological manipulations in humans, monkeys, and rodents, and involve parental attachment and caregiving, social play, aggressiveness, cooperation, and sexual behaviour. We conclude that serotonin is positively correlated with sensitivity to social factors and modulates social behaviour in a 'for-better-and-for-worse' manner, depending on the nature of social factors. Simultaneously, these behavioural responses influence the serotonergic system, leading to highly complex bidirectional serotonin×environment interaction.
血清素（5-HT）是一种古老的分子，它指导着对环境刺激的行为反应。社会环境是最强大的环境因素。人们普遍认识到，5-HT 在塑造社会反应方面起着关键作用，而血清素能系统本身对社会影响高度敏感。本综述旨在提供一系列有代表性的论文的概述，这些论文对理解血清素在互惠社会互动中的作用提供了一个连贯的观点。这里回顾的研究使用 pubmed 搜索词“社会行为”和“血清素”选择，描述了人类、猴子和啮齿动物中血清素能基因变异和药物处理的影响，并涉及父母依恋和养育、社交游戏、攻击性、合作和性行为。我们的结论是，血清素与对社会因素的敏感性呈正相关，并以“好坏参半”的方式调节社会行为，具体取决于社会因素的性质。同时，这些行为反应影响血清素能系统，导致高度复杂的双向血清素×环境相互作用。
