Department of Psychiatry, Harvard Medical School & Massachusetts General Hospital, Charlestown, MA, USA.
Biol Psychol. 2012 Feb;89(2):450-9. doi: 10.1016/j.biopsycho.2011.12.012. Epub 2011 Dec 26.
We investigated whether resting brain metabolism can be used to predict autonomic and neuronal responses during fear conditioning in 20 healthy humans. Regional cerebral metabolic rate for glucose was measured via positron emission tomography at rest. During conditioning, autonomic responses were measured via skin conductance, and blood oxygen level dependent signal was measured via functional magnetic resonance imaging. Resting dorsal anterior cingulate metabolism positively predicted differentially conditioned skin conductance responses. Midbrain and insula resting metabolism negatively predicted midbrain and insula functional reactivity, while dorsal anterior cingulate resting metabolism positively predicted midbrain functional reactivity. We conclude that resting metabolism in limbic areas can predict some aspects of psychophysiological and neuronal reactivity during fear learning.
我们研究了静息大脑代谢是否可以用于预测 20 名健康人类在恐惧条件反射期间的自主和神经元反应。通过正电子发射断层扫描在静息状态下测量葡萄糖的局部脑代谢率。在条件反射期间，通过皮肤电导率测量自主反应，通过功能磁共振成像测量血氧水平依赖性信号。静息背侧前扣带皮层代谢与差异条件反射的皮肤电导率反应呈正相关。中脑和岛叶的静息代谢与中脑和岛叶的功能反应呈负相关，而背侧前扣带皮层的静息代谢与中脑的功能反应呈正相关。我们得出结论，边缘区域的静息代谢可以预测恐惧学习过程中某些心理生理和神经元反应的方面。
