扣带皮层中负性情绪、疼痛和认知控制的整合。
The integration of negative affect, pain and cognitive control in the cingulate cortex.
机构信息
Department of Psychology, University of Wisconsin, Madison, Wisconsin, WI 53706, USA.
出版信息
Nat Rev Neurosci. 2011 Mar;12(3):154-67. doi: 10.1038/nrn2994.
Abstract
It has been argued that emotion, pain and cognitive control are functionally segregated in distinct subdivisions of the cingulate cortex. However, recent observations encourage a fundamentally different view. Imaging studies demonstrate that negative affect, pain and cognitive control activate an overlapping region of the dorsal cingulate--the anterior midcingulate cortex (aMCC). Anatomical studies reveal that the aMCC constitutes a hub where information about reinforcers can be linked to motor centres responsible for expressing affect and executing goal-directed behaviour. Computational modelling and other kinds of evidence suggest that this intimacy reflects control processes that are common to all three domains. These observations compel a reconsideration of the dorsal cingulate's contribution to negative affect and pain.
摘要
有人认为，情绪、疼痛和认知控制在扣带回皮层的不同细分区域中是功能分离的。然而，最近的观察结果鼓励了一种截然不同的观点。影像学研究表明，负性情绪、疼痛和认知控制会激活背侧扣带回的重叠区域——前扣带中间回（aMCC）。解剖学研究揭示，aMCC 构成了一个枢纽，在这里，关于强化物的信息可以与负责表达情感和执行目标导向行为的运动中心联系起来。计算模型和其他类型的证据表明，这种紧密联系反映了三个领域共有的控制过程。这些观察结果迫使人们重新考虑背侧扣带回对负性情绪和疼痛的贡献。
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