Kaçar Ayper, Paker Irem, Orhan Diclehan, Poyraz Aylar, Okçu Heper Aylin, Arda Nilüfer, Boduroğlu Esin
Department of Pathology, Ankara Children's Hematology and Oncology Research and Training Hospital, Ankara, Turkey.
Turk Patoloji Derg. 2012;28(1):24-30. doi: 10.5146/tjpath.2012.01093.
In this study, we aimed to give a documentation of 37 cases of childhood fibroblastic/myofibroblastic tumors retrieved from the archives of 6 reference centers in Ankara along with a comprehensive review on the subject.
A retrospective archive search was carried out for the period between 2006-2010 in 6 reference centers in Ankara covering patients with ages ranging between 0-18 years. All the tumors categorized under fibroblastic and myofibroblastic group according to World Health Organization criteria were collected.
The study comprised 407 soft tissue tumors in total. Fibroblastic/myofibroblastic tumors constituted 9,1 % (37 cases) of these tumors. According to histopathology; 16 cases were categorized as fibromatosis, 8 cases as inflammatory myofibroblastic tumor, 6 cases as infantile fibrous hamartoma, 3 cases as nodular fasciitis and 2 cases as infantile myofibroblastic tumor/myofibromatosis and 1 case as cranial fasciitis. The only malignant case was an infantile fibrosarcoma.
Infantile fibrosarcoma was lower than reported series and a male predominance was noted. The low incidence of newly described entities as well suggests that these tumors may have been unrecognized.
在本研究中，我们旨在记录从安卡拉6个参考中心档案中检索出的37例儿童成纤维细胞/肌成纤维细胞肿瘤病例，并对该主题进行全面综述。
对2006年至2010年期间安卡拉6个参考中心年龄在0至18岁的患者进行回顾性档案检索。收集所有根据世界卫生组织标准归类为成纤维细胞和肌成纤维细胞组的肿瘤。
该研究共包括407例软组织肿瘤。成纤维细胞/肌成纤维细胞肿瘤占这些肿瘤的9.1%（37例）。根据组织病理学；16例归类为纤维瘤病，8例为炎性肌成纤维细胞肿瘤，6例为婴儿纤维性错构瘤，3例为结节性筋膜炎，2例为婴儿肌成纤维细胞肿瘤/肌纤维瘤病以及1例为颅骨筋膜炎。唯一的恶性病例是婴儿纤维肉瘤。
婴儿纤维肉瘤低于报道系列，且注意到男性占优势。新描述实体的低发病率也表明这些肿瘤可能未被识别。
