深部脑刺激治疗儿童药物难治性危及生命的肌张力障碍状态
Deep brain stimulation for medically refractory life-threatening status dystonicus in children.
作者信息
Walcott Brian P, Nahed Brian V, Kahle Kristopher T, Duhaime Ann-Christine, Sharma Nutan, Eskandar Emad N
机构信息
Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
出版信息
J Neurosurg Pediatr. 2012 Jan;9(1):99-102. doi: 10.3171/2011.10.PEDS11360.
Abstract
Generalized dystonic syndromes may escalate into persistent episodes of generalized dystonia known as status dystonicus that can be life-threatening due to dystonia-induced rhabdomyolysis and/or respiratory compromise. Treatment of these conditions usually entails parenteral infusion of antispasmodic agents and sedatives and occasionally necessitates a medically induced coma for symptom control. The authors report a series of 3 children who presented with medically intractable, life-threatening status dystonicus and were successfully treated with bilateral pallidal deep brain stimulation. Bilateral globus pallidus internus stimulation appears to be effective in the urgent treatment of medically refractory and life-threatening movement disorders.
摘要
全身性肌张力障碍综合征可能会演变为全身性肌张力障碍的持续性发作，即肌张力障碍危象，由于肌张力障碍诱发的横纹肌溶解和/或呼吸功能不全，这可能会危及生命。这些病症的治疗通常需要胃肠外输注抗痉挛药物和镇静剂，偶尔还需要进行药物诱发昏迷以控制症状。作者报告了一系列3例患有药物难治性、危及生命的肌张力障碍危象的儿童，他们通过双侧苍白球深部脑刺激成功得到治疗。双侧内侧苍白球刺激似乎对药物难治性和危及生命的运动障碍的紧急治疗有效。
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