EA 2216, Immunology and Pathology and IFR 148 ScInBioS at the European University of Brittany, and the Brest University Medical School Hospital, Brest, France.
Curr Pharm Biotechnol. 2012 Aug;13(10):2071-7. doi: 10.2174/138920112802273100.
T cells have originally occupied central stage of the debate on the type of lymphocytes governing the pathogenesis of Sjögren's syndrome (SS). However, B cells has since been substituted for T cells, and insights into their functions have revealed that they accomplish various tasks. Beyond the paradigm that T lymphocytes maintain strict control over B lymphocytes, these latter cells solicit their own help from the former, release a flurry of cytokines, and act as antigen- presenting cells. In SS, excessive of the B cell-activating factor (BAFF) may cause B-cell quantitative anomalies, such as inflation of mature B (Bm)2/Bm2' cells in the circulation, or accumulation of transitional type 2, marginal zone (MZ) and memory B cells within the exocrine gland infiltrates. These excesses are also associated with B-cell qualitative anomalies, such as the internal synthesis of BAFF, and a default mechanism that promotes the autoantibody production in ectopic germinal centers or MZ equivalents. Thus, SS should rather be conceived as a quintessential model for B cell-induced autoimmunity. Such a view opens novel prospects for treatment, and indeed B cell-ablative therapy has already been shown to be beneficial to these patients.
T 细胞最初在关于控制干燥综合征（SS）发病机制的淋巴细胞类型的争论中占据主导地位。然而，B 细胞已取代 T 细胞，对其功能的深入了解揭示了它们完成的各种任务。除了 T 淋巴细胞对 B 淋巴细胞保持严格控制的范式之外，这些 B 细胞还向 T 淋巴细胞寻求自身帮助，释放出一连串的细胞因子，并充当抗原呈递细胞。在 SS 中，B 细胞激活因子（BAFF）的过度表达可能导致 B 细胞数量异常，例如循环中成熟 B（Bm）2/Bm2'细胞的膨胀，或在外分泌腺浸润中过渡型 2、边缘区（MZ）和记忆 B 细胞的积累。这些过度表达也与 B 细胞质量异常有关，例如 BAFF 的内在合成，以及促进异位生发中心或 MZ 等效物中自身抗体产生的默认机制。因此，SS 更应被视为 B 细胞诱导自身免疫的典型模型。这种观点为治疗开辟了新的前景，事实上，B 细胞耗竭疗法已被证明对这些患者有益。
