Medicines Research Unit, Aston University, Birmingham, B4 7ET, UK.
J Microencapsul. 2012;29(3):262-76. doi: 10.3109/02652048.2011.646330. Epub 2011 Dec 30.
Target-specific delivery has become an integral area of research in order to increase bioavailability and reduce the toxic effects of drugs. As a drug-delivery option, trigger-release liposomes offer sophisticated targeting and greater control-release capabilities. These are broadly divided into two categories; those that utilise the local environment of the target site where there may be an upregulation in certain enzymes or a change in pH and those liposomes that are triggered by an external physical stimulus such as heat, ultrasound or light. These release mechanisms offer a greater degree of control over when and where the drug is released; furthermore, targeting of diseased tissue is enhanced by incorporation of target-specific components such as antibodies. This review aims to show the development of such trigger release liposome systems and the current research in this field.
靶向递药已经成为提高药物生物利用度和降低药物毒性的研究重点。作为一种药物递药方式，触发释放脂质体具有复杂的靶向性和更好的控制释放能力。这些脂质体大致可分为两类：一类是利用目标部位的局部环境，在该环境中某些酶可能会上调或 pH 值发生变化；另一类是通过外部物理刺激（如热、超声或光）触发的脂质体。这些释放机制可以更好地控制药物何时以及何地释放；此外，通过结合抗体等靶向特定成分，可以增强对病变组织的靶向性。本文旨在展示这种触发释放脂质体系统的发展以及该领域的当前研究进展。
