利用电荷平衡策略开发用于活化细胞递送的ROS触发的屏蔽脂质体。
Development of ROS-triggered masked liposomes for activated cellular delivery using a charge balance strategy.
作者信息
Mustafa Mayesha B, Lou Jinchao, Phillips Miranda A, Turner Robert F, Baccile Joshua A, Best Michael D
机构信息
Department of Chemistry, 1420 Circle Drive, Knoxville, TN 37996-1600, USA.
出版信息
Chem Commun (Camb). 2025 Feb 13;61(15):3131-3134. doi: 10.1039/d4cc06309k.
Abstract
We report a charge balance strategy for reactive oxygen species (ROS)-triggered activation of liposome cell delivery by unmasking cationic membranes. Zeta potential experiments, microplate-based vesicle interaction assays, and cellular delivery studies confirmed that modification of anionic lipid 1 by ROS led to the uncaging of cationic liposomes, thereby driving cellular association.
摘要
我们报道了一种电荷平衡策略，用于通过揭开阳离子膜来实现活性氧（ROS）触发的脂质体细胞递送激活。ζ电位实验、基于微孔板的囊泡相互作用测定以及细胞递送研究证实，ROS对阴离子脂质1的修饰导致阳离子脂质体的解笼，从而驱动细胞结合。
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