钌催化烯胺酮的合成。
Ruthenium catalyzed synthesis of enaminones.
机构信息
Department of Chemistry and Biochemistry, The University of Tulsa, Keplinger Hall, 800 South Tucker Drive, Tulsa, Oklahoma 74101, USA.
出版信息
Org Lett. 2012 Jan 20;14(2):440-3. doi: 10.1021/ol202812d. Epub 2011 Dec 29.
PMID:22208907
Abstract
The Grubbs first-generation catalyst has been found to be an effective catalyst for the synthesis of enaminones by coupling thioamides with α-diazodicarbonyl compounds. The reaction is successful in converting primary, secondary, and tertiary thioamides into their corresponding enaminones. The reaction is also suitable for the synthesis of chiral enaminones.
摘要
Grubbs 第一代催化剂已被发现是一种有效的合成烯胺酮的催化剂，通过将硫代酰胺与α-二氮二碳化合物偶联。该反应成功地将伯、仲和叔硫代酰胺转化为相应的烯胺酮。该反应也适用于手性烯胺酮的合成。
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