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热诱导的叔烯胺 C-H 酰氧基化反应：无催化剂条件下合成酰氧基查耳酮和烯胺酮。

Thermoinduced Free-Radical C-H Acyloxylation of Tertiary Enaminones: Catalyst-Free Synthesis of Acyloxyl Chromones and Enaminones.

机构信息

College of Chemistry and Chemical Engineering , Jiangxi Normal University , Nanchang 330022 , P. R. China.

出版信息

Org Lett. 2018 Jul 6;20(13):3971-3974. doi: 10.1021/acs.orglett.8b01536. Epub 2018 Jun 25.

DOI:10.1021/acs.orglett.8b01536
PMID:29939030
Abstract

In this paper, the direct acyloxylation of the α-C(sp)-H bond in tertiary β-enaminones is accomplished under catalyst-free conditions and ambient temperature by using aroyl peroxides as coupling partners. By means of a thermoinduced free-radical pathway, the present method enables facile and efficient synthesis of both acyloxylated chromones and enaminones.

摘要

本文在无催化剂、常温条件下，以过氧二苯甲酰作为偶联试剂，实现了三级 β-烯胺酮中 α-C(sp)-H 键的直接酰氧基化反应。通过热诱导自由基途径，本方法能够方便、高效地合成酰氧基化的色酮和烯胺酮。

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