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微波辅助碘催化二苄基（二糠基）二硫化物与胺的氧化偶联：一种快速高效合成硫代酰胺的方法

Microwave-assisted iodine-catalyzed oxidative coupling of dibenzyl(difurfuryl)disulfides with amines: a rapid and efficient protocol for thioamides.

作者信息

Chen Jinyang, Mei Lan, Liu Jialing, Zhong Chuntao, Yuan Binfang, Li Qiang

机构信息

College of Chemistry and Chemical Engineering, Yangtze Normal University Fuling Chongqing 408000 P. R. China

Institution of Functional Organic Molecules and Materials, School of Chemistry and Chemical Engineering, Liaocheng University No. 1, Hunan Street Liaocheng Shandong 252059 P. R. China.

出版信息

RSC Adv. 2019 Sep 10;9(49):28576-28580. doi: 10.1039/c9ra05939c. eCollection 2019 Sep 9.

DOI:10.1039/c9ra05939c
PMID:35529638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9070997/
Abstract

An efficient protocol for synthesis of thioamides was developed the microwave-assisted iodine-catalyzed oxidative coupling of dibenzyl(difurfuryl)disulfides with amines. This process is scalable and tolerates a wide spectrum of amines to deliver the corresponding products in moderate to excellent yields in 10 minutes, providing a cheap and rapid approach to thioamides.

摘要

开发了一种高效的硫代酰胺合成方法，即微波辅助碘催化二苄基（二糠基）二硫化物与胺的氧化偶联反应。该方法具有可扩展性，能耐受多种胺类，可在10分钟内以中等至优异的产率得到相应产物，为硫代酰胺的合成提供了一种廉价且快速的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aee/9070997/cebb9c4282ae/c9ra05939c-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aee/9070997/148ca98b097c/c9ra05939c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aee/9070997/57ed624e87c6/c9ra05939c-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aee/9070997/9a2524d0ea04/c9ra05939c-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aee/9070997/cebb9c4282ae/c9ra05939c-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aee/9070997/148ca98b097c/c9ra05939c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aee/9070997/57ed624e87c6/c9ra05939c-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aee/9070997/9a2524d0ea04/c9ra05939c-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aee/9070997/cebb9c4282ae/c9ra05939c-s4.jpg

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Fluorescent Probes for Studying Thioamide Positional Effects on Proteolysis Reveal Insight into Resistance to Cysteine Proteases.用于研究硫酰胺位置效应对蛋白水解影响的荧光探针揭示了对半胱氨酸蛋白酶抗性的深入了解。
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