Department of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.
J Neuroimmunol. 2012 Feb 29;243(1-2):12-7. doi: 10.1016/j.jneuroim.2011.12.002. Epub 2011 Dec 30.
Our earlier studies described a disruption of heart rate and blood pressure diurnal rhythms in mice with experimental autoimmune encephalomyelitis (EAE). The present study investigates whether these observations could be extended to additional clock-regulated rhythms in mice with EAE. Analysis of clock gene expression in the liver of EAE mice demonstrated significant variability associated with Per2 rhythmic expression. Corticosterone and leptin hormone rhythms were also altered in EAE mice. The results presented here indicate that disturbances in clock-regulated rhythms are associated with EAE and present a suitable model for investigating the relationship between circadian disruption and autoimmune inflammatory disease.
我们之前的研究描述了实验性自身免疫性脑脊髓炎 (EAE) 小鼠心率和血压昼夜节律的紊乱。本研究旨在探讨这些观察结果是否可以扩展到 EAE 小鼠的其他时钟调节节律。对 EAE 小鼠肝脏时钟基因表达的分析表明，与 Per2 节律表达相关的显著变异性。EAE 小鼠的皮质酮和瘦素激素节律也发生了改变。本研究结果表明，时钟调节节律的紊乱与 EAE 有关，并为研究昼夜节律紊乱与自身免疫性炎症性疾病之间的关系提供了一个合适的模型。
