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在针叶树日本柳杉中，非编码区的扩展连锁不平衡。

Extended linkage disequilibrium in noncoding regions in a conifer, Cryptomeria japonica.

机构信息

Department of Biology, Kyushu University, Fukuoka 812-8581, Japan.

出版信息

Genetics. 2012 Mar;190(3):1145-8. doi: 10.1534/genetics.111.136697. Epub 2011 Dec 29.

DOI:10.1534/genetics.111.136697
PMID:22209904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3296249/
Abstract

We measured linkage disequilibrium in mostly noncoding regions of Cryptomeria japonica, a conifer belonging to Cupressaceae. Linkage disequilibrium was extensive and did not decay even at a distance of 100 kb. The average estimate of the population recombination rate per base pair was 1.55 × 10(-5) and was <1/70 of that in the coding regions. We discuss the impact of low recombination rates in a large part of the genome on association studies.

摘要

我们测量了属于柏科的针叶树日本柳杉的大部分非编码区域的连锁不平衡。连锁不平衡是广泛的，即使在 100 kb 的距离上也没有衰减。每个碱基对的种群重组率的平均估计值为 1.55×10(-5)，<1/70 编码区域的重组率。我们讨论了基因组的大部分区域的低重组率对关联研究的影响。

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