探索激酶抑制剂作为治疗人类沙粒病毒感染的方法。
Exploring kinase inhibitors as therapies for human arenavirus infections.
作者信息
Vela Eric M, Bowick Gavin C, Herzog Norbert K, Aronson Judith F
机构信息
Battelle Biomedical Research Center (BBRC), 505 King Avenue, JM8-1-096, Columbus, OH 43201-2693, USA Tel.: +1 614 424 7998; ;
出版信息
Future Virol. 2008;3(3):243-251. doi: 10.2217/17460794.3.3.243.
Abstract
Arenaviruses are rodent-borne RNA viruses, and some have the capacity to cause hemorrhagic fever and death in infected individuals and thus have been identified as a potential bioterrorism threat. Ribavirin and supportive care are currently the approved therapeutic options for individuals suffering from arenavirus-induced hemorrhagic fever. However, new research has suggested that immune plasma treatment or kinase inhibitors may provide a therapeutic option for treating arenavirus infections in humans. This article puts forth a perspective as to the potential use of kinase inhibitors as an antiviral therapeutic for arenavirus infections.
摘要
沙粒病毒是由啮齿动物传播的RNA病毒，其中一些能够在受感染个体中引发出血热并导致死亡，因此被认定为潜在的生物恐怖主义威胁。利巴韦林和支持性护理是目前获批用于治疗沙粒病毒引起的出血热患者的治疗选择。然而，新的研究表明，免疫血浆治疗或激酶抑制剂可能为治疗人类沙粒病毒感染提供一种治疗选择。本文就激酶抑制剂作为沙粒病毒感染的抗病毒治疗方法的潜在用途提出了一种观点。
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