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12 岁男孩肺炎支原体感染致暴发性、致命性多器官功能衰竭

Fulminant and Fatal Multiple Organ Failure in a 12-Year-Old Boy With Mycoplasma pneumoniae Infection.

机构信息

Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, Korea.

出版信息

Allergy Asthma Immunol Res. 2012 Jan;4(1):55-7. doi: 10.4168/aair.2012.4.1.55. Epub 2011 Nov 25.

Abstract

Mycoplasma pneumoniae (Mp) is a unique pathogen that causes not only pulmonary but also extrapulmonary manifestations that must be rapidly diagnosed. A 12-year-old boy, with no relevant medical history, presented with fever, severe epigastric pain, and vomiting. Laboratory findings showed fulminant and cholestatic hepatitis, hemolytic anemia, thrombocytopenia, acute kidney injury, disseminated intravascular coagulopathy, acute myocardial infarction, and rhabdomyolysis. His clinical condition rapidly deteriorated during intubation and continuous renal replacement therapy. Despite intensive treatment, he did not recover. We report a case of fulminant and fatal multiple organ failure in a previously healthy boy with Mp infection, describing the possible pathomechanisms of multiple organ failure involved in the disease.

摘要

肺炎支原体(Mp)是一种独特的病原体,不仅可引起肺部表现,还可引起肺外表现,必须迅速诊断。一名 12 岁男孩,无相关病史,表现为发热、严重上腹痛和呕吐。实验室检查显示暴发性和胆汁淤积性肝炎、溶血性贫血、血小板减少、急性肾损伤、弥散性血管内凝血、急性心肌梗死和横纹肌溶解。他在插管和持续肾脏替代治疗期间病情迅速恶化。尽管进行了强化治疗,但他仍未康复。我们报告了一例先前健康的男孩感染肺炎支原体导致暴发性和致命性多器官衰竭的病例,描述了该病涉及的多器官衰竭的可能发病机制。

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