Yu Initiative Research Unit, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
ACS Appl Mater Interfaces. 2012 Feb;4(2):680-6. doi: 10.1021/am2012905. Epub 2012 Jan 23.
A series of methyl- or benzyl-capped oligoethylene glycol functionalized 2,5-dibromo-3-oxythiophenes are synthesized and successfully polymerized by either Grignard metathesis (GRIM) polymerization or reductive coupling polymerization to yield the corresponding polymers in reasonable yields and molecular weights with narrow molecular weight distribution. These synthesized polyoxythiophenes exhibit high electroactivity and stability in aqueous solution when a potential is applied. Polyoxythiophenes from different polymerization approaches display different colors after purification and spectroelectrochemical studies confirm that the difference of color is from the difference of doping state. Little cytotoxicity is observed for the polymers by in vitro cell compatibility assay. NIH3T3 fibroblast cells are well attached and proliferate on spin-coated films. These results indicate that oligoethylene-glycol-functionalized polyoxythiophenes are promising candidates as conducting biomatierals for biomedical and bioengineering applications.
一系列甲氧基或苄基封端的聚乙二醇功能化 2,5-二溴-3-氧噻吩被合成，并通过 Grignard 复分解聚合或还原偶联聚合成功聚合，以合理的产率和分子量以及较窄的分子量分布得到相应的聚合物。当施加电势时，这些合成的聚噻吩在水溶液中表现出高电活性和稳定性。通过不同聚合方法得到的聚噻吩在纯化后显示出不同的颜色，光谱电化学研究证实颜色的差异来自掺杂状态的差异。通过体外细胞相容性试验观察到聚合物的细胞毒性很小。NIH3T3 成纤维细胞在旋涂薄膜上很好地附着和增殖。这些结果表明，聚乙二醇功能化聚噻吩是作为生物医学和生物工程应用的导电生物材料有前途的候选物。
