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本文引用的文献

1
Integrated 3D conducting polymer-based bioelectronics for capture and release of circulating tumor cells.用于捕获和释放循环肿瘤细胞的集成3D导电聚合物基生物电子器件。
J Mater Chem B. 2015 Jul 7;3(25):5103-5110. doi: 10.1039/c5tb00096c. Epub 2015 May 27.
2
Peptide-based isolation of circulating tumor cells by magnetic nanoparticles.基于肽的磁性纳米颗粒循环肿瘤细胞分离法。
J Mater Chem B. 2014 Jul 14;2(26):4080-4088. doi: 10.1039/c4tb00456f. Epub 2014 May 27.
3
Photoresponsive immunomagnetic nanocarrier for capture and release of rare circulating tumor cells.用于捕获和释放稀有循环肿瘤细胞的光响应免疫磁性纳米载体。
Chem Sci. 2015 Nov 13;6(11):6432-6438. doi: 10.1039/c5sc01380a. Epub 2015 Jul 30.
4
Association of AR-V7 and Prostate-Specific Antigen RNA Levels in Blood with Efficacy of Abiraterone Acetate and Enzalutamide Treatment in Men with Prostate Cancer.血液中AR-V7与前列腺特异性抗原RNA水平与醋酸阿比特龙和恩杂鲁胺治疗前列腺癌男性疗效的关联
Clin Cancer Res. 2017 Feb 1;23(3):726-734. doi: 10.1158/1078-0432.CCR-16-1070. Epub 2016 Aug 3.
5
Clinical Applications of NanoVelcro Rare-Cell Assays for Detection and Characterization of Circulating Tumor Cells.纳诺魔术贴稀有细胞检测分析在循环肿瘤细胞检测和特征鉴定中的临床应用。
Theranostics. 2016 Jun 15;6(9):1425-39. doi: 10.7150/thno.15359. eCollection 2016.
6
Near-Infrared Light-Responsive Hydrogel for Specific Recognition and Photothermal Site-Release of Circulating Tumor Cells.近红外光响应水凝胶用于循环肿瘤细胞的特异性识别和光热定点释放。
ACS Nano. 2016 Jun 28;10(6):6201-10. doi: 10.1021/acsnano.6b02208. Epub 2016 Jun 17.
7
Association of AR-V7 on Circulating Tumor Cells as a Treatment-Specific Biomarker With Outcomes and Survival in Castration-Resistant Prostate Cancer.循环肿瘤细胞上的AR-V7作为去势抵抗性前列腺癌治疗特异性生物标志物与治疗结果及生存的相关性
JAMA Oncol. 2016 Nov 1;2(11):1441-1449. doi: 10.1001/jamaoncol.2016.1828.
8
Sensitive and Specific Biomimetic Lipid Coated Microfluidics to Isolate Viable Circulating Tumor Cells and Microemboli for Cancer Detection.用于癌症检测的灵敏且特异的仿生脂质包被微流控技术，用于分离活的循环肿瘤细胞和微栓子
PLoS One. 2016 Mar 3;11(3):e0149633. doi: 10.1371/journal.pone.0149633. eCollection 2016.
9
Detection of T790M, the Acquired Resistance EGFR Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses.通过肿瘤活检与非侵入性血液分析检测T790M（获得性耐药表皮生长因子受体突变）
Clin Cancer Res. 2016 Mar 1;22(5):1103-10. doi: 10.1158/1078-0432.CCR-15-1031. Epub 2015 Oct 7.
10
Interfacing Conducting Polymer Nanotubes with the Central Nervous System: Chronic Neural Recording using Poly(3,4-ethylenedioxythiophene) Nanotubes.导电聚合物纳米管与中枢神经系统的接口：使用聚（3,4-乙撑二氧噻吩）纳米管进行慢性神经记录
Adv Mater. 2009 Oct 5;21(37):3764-3770. doi: 10.1002/adma.200900887.

聚糖刺激可实现基于 PEDOT 纳米魔术贴芯片的前列腺癌循环肿瘤细胞的纯化，从而用于 RNA 生物标志物检测。

Glycan Stimulation Enables Purification of Prostate Cancer Circulating Tumor Cells on PEDOT NanoVelcro Chips for RNA Biomarker Detection.

机构信息

Smart Organic Material Laboratory, Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Rd., Nankang, Taipei, 11529, Taiwan.

Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA, 90048, USA.

出版信息

Adv Healthc Mater. 2018 Feb;7(3). doi: 10.1002/adhm.201700701. Epub 2017 Sep 11.

DOI:10.1002/adhm.201700701
PMID:28892262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5803304/
Abstract

A glycan-stimulated and poly(3,4-ethylene-dioxythiophene)s (PEDOT)-based nanomaterial platform is fabricated to purify circulating tumor cells (CTCs) from blood samples of prostate cancer (PCa) patients. This new platform, phenylboronic acid (PBA)-grafted PEDOT NanoVelcro, combines the 3D PEDOT nanosubstrate, which greatly enhances CTC capturing efficiency, with a poly(EDOT-PBA-co-EDOT-EG3) interfacial layer, which not only provides high specificity for CTC capture upon antibody conjugation but also enables competitive binding of sorbitol to gently release the captured cells. CTCs purified by this PEDOT NanoVelcro chip provide well-preserved RNA transcripts for the analysis of the expression level of several PCa-specific RNA biomarkers, which may provide clinical insights into the disease.

摘要

一种糖刺激的和聚（3,4-亚乙基二氧噻吩）（PEDOT）基纳米材料平台被构建用于从前列腺癌（PCa）患者的血液样本中纯化循环肿瘤细胞（CTC）。这个新平台，苯硼酸（PBA）接枝的 PEDOT NanoVelcro，将 3D PEDOT 纳米基底与聚（EDOT-PBA-co-EDOT-EG3）界面层相结合，不仅在抗体偶联时提供了对 CTC 捕获的高特异性，而且还能够使山梨醇进行竞争性结合，从而温和地释放捕获的细胞。通过这种 PEDOT NanoVelcro 芯片纯化的 CTC 提供了保存完好的 RNA 转录本，可用于分析几种 PCa 特异性 RNA 生物标志物的表达水平，这可能为该疾病提供临床见解。