Spiller Henry A, Siewert Dennis J
Kentucky Regional Poison Control Center, PO Box 35070, Louisville, KY 40232, USA.
J Forensic Sci. 2012 May;57(3):835-8. doi: 10.1111/j.1556-4029.2011.02026.x. Epub 2011 Dec 28.
Drug-facilitated sexual assault (DFSA) has been defined as the use of a chemical agent to facilitate a sexual assault. We report two cases of the use of tetrahydrozoline for DFSA. We believe this is the first report with urinary quantification of tetrahydrozoline levels postassault. Blood and urine were obtained c. 20 h postexposure in two cases of reported DFSA. Tetrahydrozoline was not detected in blood but was identified in urine in both victims. After initial identification in the urine using the 2010 update to the AAFS mass spectrometry database library, tetrahydrozoline was quantified at 114 and 150 ng/mL, respectively, using GC/MS. Two unique clinical features reported in these cases were intermittent periods of consciousness and postexposure vomiting. Use of GC/MS was successful in identifying tetrahydrozoline in the 100 ng/mL range up to 20 h postexposure. For victims with late presentation, urine may be a better sample for evaluation for tetrahydrozoline.
药物辅助性性侵（DFSA）被定义为使用化学制剂促成性侵行为。我们报告了两例使用四氢唑啉进行药物辅助性性侵的案例。我们认为这是首篇对性侵后四氢唑啉水平进行尿液定量分析的报告。在两例已报告的药物辅助性性侵案例中，暴露约20小时后采集了血液和尿液样本。血液中未检测到四氢唑啉，但两名受害者的尿液中均检测到了该物质。在使用美国法医科学学会（AAFS）质谱数据库库2010年更新版对尿液进行初步鉴定后，通过气相色谱/质谱联用仪（GC/MS）对四氢唑啉进行定量分析，结果分别为114 ng/mL和150 ng/mL。这些案例中报告的两个独特临床特征为间歇性意识不清和暴露后呕吐。使用GC/MS成功鉴定出暴露后20小时内浓度在100 ng/mL范围内的四氢唑啉。对于就诊较晚的受害者，尿液可能是评估四氢唑啉的更佳样本。
