Forensic Toxicology Unit, Forensic Science Center, Oklahoma State Bureau of Investigation, Edmond, OK 73034, United States.
Forensic Sci Int. 2012 Sep 10;221(1-3):e12-6. doi: 10.1016/j.forsciint.2012.04.004. Epub 2012 May 1.
We report two cases of drug-facilitated sexual assault which presented with CNS depression rendering the victims vulnerable to sexual assault and unable to recall the events surrounding the crimes. In each tetrahydrozoline (THZ) was quantified.
Case #1 ingested an unknown amount of eye drops containing THZ mixed with alcoholic beverages. Case #1 presented to the emergency department (ED) approximately 7h after reportedly being sexually assaulted and was without symptoms in the ED. Earlier reports from individuals who saw her indicated the victim to be "heavily intoxicated". Case #2 also ingested an unknown amount of eye drops containing THZ mixed with alcoholic beverages. Case #2 presented to an ED without symptoms approximately 23h after reportedly being sexually assaulted. Urine obtained from both cases was assessed for THZ concentrations using gas-chromatography-mass spectrometry.
Case #1 had a 0.15g% (by weight by volume) urine ethanol concentration and a urinary THZ concentration of 1.481ng/ml, approximately 7h after ingestion. Case #2 was negative for ethanol but had a urine THZ concentration of 108ng/ml at 23h post-ingestion. Few case reports have been published documenting the use of THZ to facilitate sexual assault.
We report two cases of drug-facilitated sexual assault involving the use of THZ where alcoholic beverages were concomitantly consumed. This is the first paper to our knowledge which discusses pharmacology of THZ ingestion and the significance of alcohol being present.
我们报告了两例药物辅助性性侵案件，这些案件均表现为中枢神经系统抑制，使受害者易受性侵且无法回忆起犯罪事件。在每个案例中，均检测到了四氢唑啉（THZ）的存在并进行了定量分析。
案例 1 摄入了含有 THZ 的未知剂量眼药水，与酒精饮料混合。案例 1 在据称被性侵后约 7 小时到急诊部（ED）就诊，在 ED 时没有症状。较早前看到受害者的人的报告表明受害者“严重醉酒”。案例 2 也摄入了含有 THZ 的未知剂量眼药水，与酒精饮料混合。案例 2 在据称被性侵后约 23 小时到 ED 就诊，没有症状。从两个案例中获得的尿液均使用气相色谱-质谱法评估了 THZ 浓度。
案例 1 在摄入后约 7 小时，尿液乙醇浓度为 0.15g%（重量体积比），尿液 THZ 浓度为 1.481ng/ml。案例 2 乙醇检测结果为阴性，但在摄入后 23 小时尿液 THZ 浓度为 108ng/ml。已经有少数案例报告发表，记录了使用 THZ 来协助性侵的情况。
我们报告了两例涉及使用 THZ 的药物辅助性性侵案件，同时还摄入了酒精。这是我们所知的第一份讨论 THZ 摄入的药理学以及存在酒精的意义的论文。
