新型非反射测试可在临床相关浓度下检测啮齿动物的镇痛作用。
Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations.
机构信息
Pain and Sensory Disorders Research Unit, Pfizer Laboratories, Sandwich, United Kingdom.
出版信息
Ann N Y Acad Sci. 2011 Dec;1245:11-3. doi: 10.1111/j.1749-6632.2011.06342.x.
Abstract
We propose that predictive validity of tests for analgesia may be improved by looking to reinstate specific, innate behaviors suppressed by pain, e.g., burrowing, because effective plasma concentrations in the rat are closer to effective clinical plasma concentrations than those generally used in rodent reflex withdrawal assays.
摘要
我们提出，通过观察疼痛抑制的特定先天行为（如打洞）的恢复，可以提高镇痛测试的预测有效性，因为大鼠的有效血浆浓度比啮齿动物反射退缩测定中通常使用的浓度更接近有效临床血浆浓度。
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