Department of Dermatology, Complejo Hospitalario Universitario, Faculty of Medicine, Santiago de Compostela, A Coruña, Spain.
Photodermatol Photoimmunol Photomed. 2012 Feb;28(1):47-9. doi: 10.1111/j.1600-0781.2011.00632.x.
Granuloma annulare (GA) is a benign granulomatous skin disease with several clinical manifestations and characteristic histological findings. GA located in photoexposed areas is a rare finding and its association to a drug-induced systemic photosensitivity is even less common. To the best of our knowledge, only one case of systemic drug photosensitivity manifesting as a GA has been reported. We describe a patient with systemic photosensitivity to paroxetine with clinical and histological manifestations of GA, which was confirmed by the photobiological study. The phototest revealed a reduction of the minimal erythematous dose for UVB while taking the paroxetine and its normalization after its withdrawal, which was accompanied by the clinical resolution of the skin eruption. The manifestation of systemic drug photosensitivity as a GA like in our case is exceptional.
环状肉芽肿（GA）是一种良性肉芽肿性皮肤病，具有多种临床表现和特征性组织学发现。位于光暴露部位的 GA 较为罕见，其与药物诱导的全身性光敏感性相关更为少见。据我们所知，仅有一例全身性药物光敏感性表现为 GA 的病例报告。我们描述了一例帕罗西汀引起的全身性光敏感性患者，其临床表现和组织学均符合 GA，这通过光生物学研究得到了证实。光试验显示，在服用帕罗西汀时，UVB 的最小红斑剂量减少，停药后恢复正常，同时皮肤疹消退。像我们的病例这样，全身性药物光敏感性表现为 GA 是罕见的。
