Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
Mayo Clin Proc. 2012 Jan;87(1):17-24. doi: 10.1016/j.mayocp.2011.08.001.
To study the frequencies of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, and their associations with hepatocellular carcinoma (HCC) in immigrant Somalis seen at Mayo Clinic in Rochester, Minnesota.
We determined the frequencies of HBV and HCV infection and HCC in immigrant Somalis seen at Mayo Clinic from July 1, 1996, through October 31, 2009. Non-Somali Olmsted County residents served as controls.
For Somali males and females, age-adjusted proportions (per 1000 population) were 209 and 123 for hepatitis B surface antigen (HBsAg), 644 and 541 for hepatitis B core antibody (HBcAb), and 99 and 66 for anti-HCV. The comparative proportions in non-Somalis were 20 and 9 for HBsAg, 126 and 97 for HBcAb, and 32 and 17 for anti-HCV. Hepatitis C virus RNA confirmed that 68 of 73 Somalis (93.2%) and 261 of 282 non-Somalis (92.6%) with positive anti-HCV test results had active HCV infection. Of 30 Somali patients with HCC, 22 (73.3%) tested anti-HCV positive (odds ratio [OR], 31.3; 95% confidence interval [CI], 13.0-75.5; P<.001; compared with anti-HCV-negative Somalis), 5 (16.7%) were HBsAg positive (OR, 1.4; 95% CI, 0.5-3.7; P=.53), and 18 (60.0%) were HBcAb positive (OR, 1.8; 95% CI, 0.8-4.2; P=.16). Viral hepatitis was diagnosed coincident with HCC in 9 of 20 patients (45.0%) with HCV-associated HCCs. Only 4 of 24 cases of HCC (16.7%) were detected during surveillance.
Both HBV and HCV occurred frequently in this sample of Somali immigrants. However, HCV was the major risk factor for HCC. Screening Somali immigrants for HCV infection may enhance the prevention, early detection, and optimal treatment of HCC.
研究在明尼苏达州罗彻斯特市梅奥诊所就诊的移民索马里人中慢性乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染的频率及其与肝细胞癌（HCC）的关系。
我们确定了 1996 年 7 月 1 日至 2009 年 10 月 31 日在梅奥诊所就诊的移民索马里人的 HBV 和 HCV 感染和 HCC 的频率。非索马里奥姆斯特德县居民作为对照。
对于索马里男性和女性，乙型肝炎表面抗原（HBsAg）的年龄调整比例（每 1000 人）分别为 209 和 123，乙型肝炎核心抗体（HBcAb）为 644 和 541，抗 HCV 为 99 和 66。非索马里人的相应比例分别为 20 和 9 用于 HBsAg，126 和 97 用于 HBcAb，32 和 17 用于抗 HCV。丙型肝炎病毒 RNA 证实，73 名索马里人中的 68 名（93.2％）和 282 名非索马里人中的 261 名（92.6％）抗 HCV 检测结果阳性者均有活动性 HCV 感染。在 30 名患有 HCC 的索马里患者中，22 名（73.3％）抗 HCV 阳性（比值比[OR]，31.3；95％置信区间[CI]，13.0-75.5；P<.001；与抗 HCV 阴性的索马里人相比），5 名（16.7％）HBsAg 阳性（OR，1.4；95％CI，0.5-3.7；P=.53），18 名（60.0％）HBcAb 阳性（OR，1.8；95％CI，0.8-4.2；P=.16）。9 例（45.0％）HCV 相关 HCC 患者的丙型肝炎病毒相关 HCC 与 HCC 同时诊断为病毒性肝炎。仅在 24 例 HCC 病例中发现了 4 例（16.7％）（在监测中发现）。
在这组索马里移民样本中，HBV 和 HCV 均频繁发生。然而，HCV 是 HCC 的主要危险因素。对索马里移民进行 HCV 感染筛查可能会增强 HCC 的预防，早期发现和最佳治疗。
