Lindqvist C
Am J Epidemiol. 1979 May;109(5):521-30. doi: 10.1093/oxfordjournals.aje.a112710.
An analysis was made of potential risk factors of cancer of the lip in Finland. The series comprised 290 lip cancer patients, and the controls were 254 patients with squamous cell carcinoma of the skin of the head and neck, all reported to the Finnish Cancer Registry in 1972-1973. The results obtained in a questionnaire survey (response rate, 75%; 54% of the total series) indicated that the male lip cancer patients had engaged in outdoor work and smoking with significantly greater frequency than had the male controls. Together, these two risk factors posed a markedly increased risk (RR = 15.4). However, when the factors were analyzed separately, each excluding the effect of the other, no significant risk could be noted. The male lip cancer patients had recurrent herpetic infections with significantly greater frequency than did the male controls. No significant differences were apparent with respect to urban or rural residence. It is concluded that tobacco smoking and outdoor work probably act together to induce lip cancer. The mode of interaction between these factors and the etiologic role of herpesvirus are discussed.
对芬兰唇癌的潜在风险因素进行了分析。该系列包括290例唇癌患者，对照组为254例头颈部皮肤鳞状细胞癌患者，所有病例均于1972 - 1973年上报至芬兰癌症登记处。问卷调查结果（回复率75%；占总系列的54%）表明，男性唇癌患者从事户外工作和吸烟的频率明显高于男性对照组。这两个风险因素共同作用使风险显著增加（相对危险度RR = 15.4）。然而，当分别分析这些因素，排除彼此的影响时，未发现显著风险。男性唇癌患者复发性疱疹感染的频率明显高于男性对照组。在城乡居住方面未发现显著差异。结论是，吸烟和户外工作可能共同作用诱发唇癌。讨论了这些因素之间的相互作用模式以及疱疹病毒的病因学作用。
