Department of Dermatology, Gulhane School of Medicine, Ankara, Turkey.
J Dermatolog Treat. 2013 Aug;24(4):300-4. doi: 10.3109/09546634.2011.649690. Epub 2012 Jan 31.
To evaluate and compare the safety and efficacy of 10% potassium hydroxide (KOH) solution and salicylic and lactic acid (SAL + LAC) combination in the treatment of molluscum contagiosum (MC).
26 patients with MC randomized into two treatment groups. 12 patients treated with 10% KOH solution and 14 patients treated with SAL + LAC combination for 6 weeks. Parents of patients were instructed to apply medication once daily only to lesions at study onset. Assessment of response of the treated lesions and side effects was performed at 2, 4 and 6 weeks of the treatment. Newly acquired lesions were not included in the study.
At the end of therapy, 83.3% (n = 10) of KOH group demonstrated complete remission and 16.7% (n = 2) of them showed partial remission; four patients (33%) developed new lesions during the study. All the patients in the SAL + LAC combination group (100%) demonstrated complete remission of study entry lesions at the end of 6 weeks with five patients (35%) acquiring new lesions during the study. Minor side effects were observed in two groups.
10% KOH solution and SAL + LAC combination were found to be equally effective in the treatment of MC in children.
评估和比较 10%氢氧化钾（KOH）溶液和水杨酸与乳酸（SAL+LAC）联合治疗传染性软疣（MC）的安全性和疗效。
将 26 例 MC 患者随机分为两组治疗。12 例患者用 10%KOH 溶液治疗，14 例患者用 SAL+LAC 联合治疗 6 周。在研究开始时，告知患者家长每天仅将药物涂抹于病变部位。在治疗的第 2、4 和 6 周时，评估治疗病变的反应和不良反应。新获得的病变不包括在研究中。
治疗结束时，KOH 组 83.3%（n=10）的患者完全缓解，16.7%（n=2）的患者部分缓解；4 名患者（33%）在研究期间出现新的病变。SAL+LAC 联合组所有患者（100%）在 6 周时完全缓解了研究开始时的病变，5 名患者（35%）在研究期间出现新的病变。两组均观察到轻微的不良反应。
10%KOH 溶液和 SAL+LAC 联合治疗儿童 MC 同样有效。
