Department of Dermatology, University of Medeniyet Goztepe Training and Research Hospital , Istanbul , Turkey.
J Dermatolog Treat. 2014 Jun;25(3):246-8. doi: 10.3109/09546634.2012.697988. Epub 2012 Jul 25.
Molluscum contagiosum (MC) is a common cutaneous viral infection of the skin that is frequently seen in children. Although lesions can resolve spontaneously, treatment is mandatory because of the psychological effect of widespread lesions in children. Potassium hydroxide (KOH) is a strong alkali that has been used by dermatologists for a long time in identifying the fungal infections from skin scrapings.
We evaluated 40 children with MC for the safety and efficacy of treatment with topical 10% KOH aqueous solution.
Parents were instructed to apply a 10% KOH aqueous solution, twice daily, with a cotton stick to all lesions. Treatment was continued till the lesions showed signs of inflammation or superficial ulceration. Assessments of response and side effects were performed at the end of week 2, week 4, week 8 and week 12.
We found complete clearance of lesions in 37 (92.5%) patients receiving topical 10%KOH solution after a mean period of four weeks. Three children dropped out of the study; two children reported severe stinging of the lesions and discontinued the treatment; the other patient developed hypopigmentation during the treatment. Local side effects were observed in 12 children (32.4%).
Even though 10% KOH solution is associated with some local side effects, it is a safe, effective, inexpensive and noninvasive alternative treatment of MC in children.
传染性软疣（MC）是一种常见的皮肤病毒性感染，常见于儿童。虽然病变可以自行消退，但由于广泛病变对儿童的心理影响，治疗是强制性的。氢氧化钾（KOH）是一种强碱，皮肤科医生长期以来一直用于从皮肤刮片中识别真菌感染。
我们评估了 40 例 MC 患儿使用 10％KOH 水溶液治疗的安全性和疗效。
指导家长每天用棉棒将 10％KOH 水溶液涂于所有病变两次。治疗持续到病变出现炎症或浅表溃疡迹象为止。在第 2 周、第 4 周、第 8 周和第 12 周结束时评估反应和副作用。
我们发现，接受 10％KOH 溶液治疗的 37 名（92.5％）患者在平均四周后病变完全清除。有 3 名儿童退出研究；2 名儿童报告病变刺痛严重而停止治疗；另一名患者在治疗过程中出现色素减退。12 名儿童（32.4％）出现局部副作用。
尽管 10％KOH 溶液与一些局部副作用有关，但它是儿童 MC 的一种安全、有效、经济且非侵入性的替代治疗方法。
