Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, USA.
Int J Neuropsychopharmacol. 2012 Oct;15(9):1241-9. doi: 10.1017/S1461145711001805. Epub 2012 Jan 4.
The purpose of this study was to evaluate the effects of acute, oral modafinil (200 mg) exposure on daytime sleepiness in methamphetamine (Meth)-dependent individuals. Eighteen Meth-dependent subjects were enrolled in a 7-d inpatient study and were administered placebo or modafinil on day 6 and the counter-condition on day 7 (randomized) of the protocol. Subjects completed several subjective daily assessments (such as the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Beck Depression Inventory and visual analogue scale) throughout the protocol as well as objective assessments on days 5-7, when the Multiple Sleep Latency Test was performed. The results of the current study suggest that short-term abstinence from Meth is associated with increased daytime sleepiness and that a single dose of 200 mg modafinil reduces daytime somnolence in this population. In addition, a positive correlation was found between subjective reporting of the likelihood of taking a nap and craving and desire for Meth, as well as the likelihood of using Meth and whether Meth would make the participant feel better. The results of this study should be considered when investigating candidate medications for Meth-dependence, especially in those individuals who attribute their Meth use to overcoming deficits resulting from sleep abnormalities.
本研究旨在评估急性口服莫达非尼（200 毫克）对甲基苯丙胺（Meth）依赖者日间嗜睡的影响。18 名 Meth 依赖者被纳入为期 7 天的住院研究，并在方案的第 6 天和第 7 天（随机）给予安慰剂或莫达非尼。在整个方案中，受试者完成了几项主观日常评估（如嗜睡量表、匹兹堡睡眠质量指数、贝克抑郁量表和视觉模拟量表），以及在第 5-7 天进行多次睡眠潜伏期测试时的客观评估。目前的研究结果表明，短期戒断 Meth 与日间嗜睡增加有关，而单次 200 毫克莫达非尼可减少该人群的日间嗜睡。此外，还发现主观报告小睡的可能性与对 Meth 的渴望和欲望，以及使用 Meth 的可能性以及 Meth 是否会让参与者感觉更好之间存在正相关。在研究 Meth 依赖的候选药物时，特别是在那些将自己的 Meth 使用归因于克服睡眠异常导致的缺陷的个体中，应考虑本研究的结果。
