Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
Mod Pathol. 2012 Jan;25 Suppl 1:S1-10. doi: 10.1038/modpathol.2011.151.
Classification of adenocarcinoma has undergone recent evaluation to better align histological classification with clinical outcomes. One terminology, in particular, that of bronchioloalveolar carcinoma (BAC), has been debated for many decades. Although initial discussion surrounded the cell-of-origin of this tumor, more recent confusion has been generated from the use of this term both as a pattern of growth within an otherwise invasive adenocarcinoma and as a term for a pre-invasive tumor synonymous with adenocarcinoma in situ. As a result, adenocarcinomas with quite different radiology, gross morphology and metastatic potential have been associated with the BAC term. Focusing on invasion and using an illustrative case, we will explore the current recommendations that incorporate assessment of invasion to clarify the confusion caused by the different uses of the historical term 'BAC'.
腺癌的分类最近进行了评估，以便更好地将组织学分类与临床结果相匹配。特别是有一个术语，即细支气管肺泡癌（BAC），已经争论了几十年。虽然最初的讨论围绕着这种肿瘤的细胞起源，但最近由于这个术语既被用作一种生长模式，存在于其他侵袭性腺癌中，又被用作一种术语，用于指代一种与原位腺癌同义的前侵袭性肿瘤，因此引起了混淆。因此，具有不同影像学、大体形态和转移潜能的腺癌与 BAC 术语有关。通过关注浸润，我们将使用一个说明性的病例来探讨当前的建议，这些建议纳入了浸润评估，以澄清由历史术语“BAC”的不同用法引起的混淆。
