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皮肤利什曼病——1例在免疫反应正常情况下治疗后仍有持续病原体的病例。

Cutaneous leishmaniasis--a case with persistent organisms after treatment in presence of normal immune response.

作者信息

Neva F A, Wyler D, Nash T

出版信息

Am J Trop Med Hyg. 1979 May;28(3):467-71.

PMID:222157
Abstract

A Peace Corps volunteer in Senegal, West Africa contracted cutaneous leishmaniasis which had several noteworthy features. One of the three presenting cutaneous ulcers was associated with subcutaneous nodules and viable organisms were recovered from healing lesions after multiple courses of treatment, including amphotericin B. Yet, the patient was found to exhibit both humoral and cell mediated features of normal immunologic responsiveness. Ultimately, clinical and parasitological cure occurred. The patient's organism was found to produce lesions in the foot pads of mice.

摘要

一名在西非塞内加尔的和平队志愿者感染了皮肤利什曼病,该病有几个值得注意的特征。三个出现的皮肤溃疡中有一个与皮下结节有关,在包括两性霉素B在内的多个疗程治疗后,从愈合的病灶中发现了活的病原体。然而,发现该患者表现出正常免疫反应的体液和细胞介导特征。最终,实现了临床和寄生虫学治愈。发现该患者的病原体在小鼠脚垫上产生病变。

相似文献

1
Cutaneous leishmaniasis--a case with persistent organisms after treatment in presence of normal immune response.皮肤利什曼病——1例在免疫反应正常情况下治疗后仍有持续病原体的病例。
Am J Trop Med Hyg. 1979 May;28(3):467-71.
2
[Successful treatment of antimony-resistant cutaneous leishmaniasis].
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Experimental therapy of mice infected with Leishmania tropica.感染热带利什曼原虫的小鼠的实验性治疗
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[Cutaneous leishmaniasis in 49 patients in The Netherlands].[荷兰49例皮肤利什曼病患者]
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Successful treatment of post-kala-azar dermal leishmaniasis (PKDL) in a HIV infected patient with multiple relapsing leishmaniasis from Western Europe.成功治疗一名来自西欧的、患有多重复发性利什曼病的HIV感染患者的黑热病后皮肤利什曼病(PKDL)。
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Treatment of experimental cutaneous leishmaniasis by liposome-entrapped Pentostam.
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Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania.实验杂种的全基因组测序支持利什曼原虫中类似减数分裂的性重组。
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Mannose receptor high, M2 dermal macrophages mediate nonhealing infection in a Th1 immune environment.甘露糖受体高表达,M2 皮肤巨噬细胞在 Th1 免疫环境中介导慢性感染。
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The Nlrp3 inflammasome, IL-1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice.Nlrp3炎性小体、白细胞介素-1β和中性粒细胞募集是C57BL/6小鼠对不愈合的硕大利什曼原虫菌株易感性所必需的。
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