Eleftheriadis E, Kotzampassi K, Aletras H
Department of Surgery, University of Thessaloniki, Greece.
Am Surg. 1990 Oct;56(10):593-5.
Hemodynamic events and structural vascular changes of the gastric mucosa in cirrhotics have caught the attention of investigators in the recent past, but as yet it is not known whether therapeutic interruption of variceal blood flow at gastroesophageal level alters such portal hypertensive mucosal features. The newly developed endoscopic laser-Doppler technique was used to assess whether variceal eradication by means of endoscopic sclerotherapy influences the gastric mucosal congestion in portal hypertension patients. Gastric mucosal blood flow was determined at ten defined sites of the stomach, before the first session of sclerotherapy and after complete variceal eradication had been achieved in 15 patients. A statistically significant decrease (P less than 0.01 to 0.05) in microcirculation was found at the gastric antrum and corpus, an increase at the pylorus (P less than 0.05), but no change in the fundic area. An important question following these findings is: What are the consequences of such aggravation of gastric congestion on the integrity of the gastric mucosa?
近年来，肝硬化患者胃黏膜的血流动力学事件和血管结构变化引起了研究人员的关注，但目前尚不清楚在胃食管水平对曲张静脉血流进行治疗性阻断是否会改变这种门静脉高压性黏膜特征。新开发的内镜激光多普勒技术被用于评估内镜硬化疗法根除曲张静脉是否会影响门静脉高压患者的胃黏膜充血情况。在15例患者首次进行硬化治疗前以及曲张静脉完全根除后，在胃的10个特定部位测定胃黏膜血流。发现胃窦和胃体的微循环有统计学意义的下降（P小于0.01至0.05），幽门处增加（P小于0.05），但胃底部区域无变化。基于这些发现的一个重要问题是：胃充血加重对胃黏膜完整性会有什么后果？
