正常受试者三种下丘脑激素（TRH、LH/FSH-RH、GH-RIH）短期作用的脑电图研究。
An electroencephalographic investigation of short-term effects of three hypothalamic hormones (TRH, LH/FSH-RH, GH-RIH) in normal subjects.
机构信息
Clinical Psychopharmacology Unit, Department of Pharmacological Sciences, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne.
出版信息
Br J Clin Pharmacol. 1976 Aug;3(4):523-31. doi: 10.1111/j.1365-2125.1976.tb04871.x.
Three hypothalamic regulatory hormones, thyrotrophin-releasing hormone (TRH), luteinizing hormone/follicle-stimulating hormone-releasing hormone (LH/FSH-RH) and growth hormone-release inhibiting hormone (GH-RIH) given intravenously had no effect on the electroencephalographic response known as the contingent negative variation (CNV) in normal subjects. TRH was given as a 10 ml infusion of 600 microg over 8 min to six subjects. This produced subjective sensations and a rise in heart rate but no significant alteration of CNV magnitude. LH/FSH-RH was given in a dose of 200 microg in 10 ml over 2 min to six subjects. This had no effect on CNV magnitude or heart rate and produced no subjective effects. GH-RIH was given as a 10 ml infusion of 250 microg over 10 min to six subjects. Again there was no alteration in the magnitude of the CNV; the heart rate was slowed.
三种下丘脑调节激素，促甲状腺素释放激素（TRH）、黄体生成素/卵泡刺激素释放激素（LH/FSH-RH）和生长激素释放抑制激素（GH-RIH）经静脉注射对正常受试者的称为条件负变（CNV）的脑电图反应没有影响。TRH 以 600μg 的 10ml 输注在 8 分钟内给予 6 名受试者。这产生了主观感觉和心率升高，但 CNV 幅度没有明显改变。LH/FSH-RH 以 10ml 中的 200μg 在 2 分钟内给予 6 名受试者。这对 CNV 幅度或心率没有影响，也没有产生主观影响。GH-RIH 以 10ml 中的 250μg 在 10 分钟内输注给予 6 名受试者。CNV 的幅度也没有改变；心率减慢。
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