University of Maryland, College Park, MD 20742, USA.
Bioorg Med Chem Lett. 2012 Jan 15;22(2):881-5. doi: 10.1016/j.bmcl.2011.12.039. Epub 2011 Dec 16.
C-di-GMP has emerged as an important bacterial signaling molecule that is involved in biofilm formation. Small molecules that can form biologically inactive complexes with c-di-GMP have the potential to be used as anti-biofilm agents. Herein, we report that water-soluble diamidinium/iminium aromatics (such as berenil), which are traditionally considered as minor groove binders of nucleic acids, are capable of aggregating c-di-GMP into G-quadruplexes via π-stacking interactions.
c-di-GMP 已成为一种重要的细菌信号分子，参与生物膜的形成。能够与 c-di-GMP 形成无生物活性复合物的小分子有可能被用作抗生物膜剂。在此，我们报告称，水溶性二脒/亚胺芳烃（如贝伦宁）传统上被认为是核酸的小沟结合物，能够通过 π-堆积相互作用将 c-di-GMP 聚集形成 G-四链体。
