氧氟沙星、庆大霉素和妥布霉素在泪液中的浓度与90%受试微生物体外最低抑菌浓度的比较。 （注：原文中多了一个of，正确句子应该是Comparison of ofloxacin, gentamicin, and tobramycin concentrations in tears and in vitro MICs for 90% of test organisms. ）
Comparison of ofloxacin, gentamicin, and tobramycin concentrations in tears and in vitro MICs for 90% of test organisms.
作者信息
Richman J, Zolezio H, Tang-Liu D
机构信息
Allergan Pharmaceuticals, Irvine, California 92715.
出版信息
Antimicrob Agents Chemother. 1990 Aug;34(8):1602-4. doi: 10.1128/AAC.34.8.1602.
Abstract
Concentrations of three anti-infective agents in tear film were monitored after one topical application in rabbits. Ofloxacin concentrations exceeded the MIC for 90% of the organisms tested (MIC90) (gram-negative and gram-positive organisms) for 240 min. Tobramycin concentrations exceeded the MIC90 for 10 min. Gentamicin concentrations exceeded the MIC90 for 20 min for gram-positive organisms and 120 min for gram-negative organisms.
摘要
在兔眼局部应用一次后，监测泪膜中三种抗感染药物的浓度。氧氟沙星浓度超过90%受试微生物（革兰氏阴性菌和革兰氏阳性菌）的最低抑菌浓度（MIC90）达240分钟。妥布霉素浓度超过MIC90达10分钟。庆大霉素浓度对革兰氏阳性菌超过MIC90达20分钟，对革兰氏阴性菌超过MIC90达120分钟。
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