Speciale A, Stefani S, Caccamo F, Nicolosi V M, Nicoletti G
Institute of Microbiology, University of Catania, Italy.
Drugs Exp Clin Res. 1987;13(9):555-61.
The in vitro antimicrobial activity of ofloxacin, a new fluorinated quinolone, was evaluated against 165 Gram-negative rods, both fermentative and non-fermentative, and against 57 Gram-positive strains (coagulase-positive and -negative staphylococci both methicillin-resistant and -susceptible, and Streptococcus faecalis). Minimal inhibitory concentrations were determined by using the macrodilution test and the activity was compared with nalidixic acid, norfloxacin, ampicillin, piperacillin, ceftazidime and gentamicin for Gram-negative rods; norfloxacin and gentamicin for Staphylococcus strains; and norfloxacin, ampicillin, piperacillin and gentamicin for enterococci. Ofloxacin inhibited all fermentative Gram-negative bacteria tested, in a range of 0.05-3.12 mcg/ml, and had good antimicrobial activity against non-fermentative Gram-negative strains: it inhibited 90% of Acinetobacter and 80% of P. aeruginosa tested, at 3.12 mcg/ml. Ofloxacin had a high antimicrobial activity against Staphylococcus and Enterococcus strains tested.
对一种新型氟喹诺酮类药物氧氟沙星的体外抗菌活性进行了评估，受试对象包括165株革兰氏阴性杆菌（发酵型和非发酵型）以及57株革兰氏阳性菌株（凝固酶阳性和阴性葡萄球菌，包括耐甲氧西林和对甲氧西林敏感的菌株，还有粪肠球菌）。采用常量稀释试验测定最低抑菌浓度，并将其活性与萘啶酸、诺氟沙星、氨苄西林、哌拉西林、头孢他啶和庆大霉素针对革兰氏阴性杆菌的活性进行比较；与诺氟沙星和庆大霉素针对葡萄球菌菌株的活性进行比较；与诺氟沙星、氨苄西林、哌拉西林和庆大霉素针对肠球菌的活性进行比较。氧氟沙星抑制了所有受试的发酵型革兰氏阴性菌，最低抑菌浓度范围为0.05 - 3.12微克/毫升，并且对非发酵型革兰氏阴性菌株具有良好的抗菌活性：在3.12微克/毫升时，它抑制了90%的受试不动杆菌和80%的受试铜绿假单胞菌。氧氟沙星对受试的葡萄球菌和肠球菌菌株具有较高的抗菌活性。
