Department of Radiobiology and Radiation Protection, Cellular and Molecular Research Center, Babol University of Medical Sciences, Babol, Iran.
Med Oncol. 2012 Dec;29(4):2552-5. doi: 10.1007/s12032-011-0153-0. Epub 2012 Jan 5.
Radiosensitivity is a biological response to radiation. This response depends on many factors such as radiation factors as well as biological system factors. It is shown that identical doses of radiation for the treatment of Cancer patients produce different biological responses that are assumed to be depend on different specifications of the biological systems. However, by elimination of these factors, people may still show different biological responses such as acute and low responses to radiotherapy in similar doses of radiation. Some reports indicate that breast cancer, immune diseases including autoimmune diseases such as lupus, Myasthenia Gravies and even the rate of allergy are more frequent in left-handed compared to right-handed individuals. The main goal of the present study is determination of radiosensitivity in left-handed compared to right-handed in breast cancer women by cytogenetic assay. Peripheral venous blood samples (10 ml) of 30 breast cancer women (10 left- and 20 right-handed) were divided into two identical parts. One part is exposed to 2 Gy Co-60 gamma rays, and the second part is considered as non-exposed controls. Lymphocytes were cultured in standard media, and cytokinesis blocked to score micronuclei in bi-nucleated cells. The frequency of micronuclei in 1,000 cells in each sample is considered as the rate of radiosensitivity and was compared in left- and right-handed breast cancer women by appropriate statistical analysis. Results showed that radiosensitivity index in left-handers is higher than right-handers also mean frequency of MN in exposed group of left-handers compare to right-handers is elevated. It seems that left-handed breast cancer women are more radiosensitive than right-handed. More investigations on right- and left-handed healthy people are ongoing in our laboratory.
辐射敏感性是对辐射的生物学反应。这种反应取决于许多因素，如辐射因素以及生物系统因素。研究表明，对癌症患者进行相同剂量的放射治疗会产生不同的生物学反应，这些反应被认为取决于生物系统的不同特性。然而，通过消除这些因素，人们仍然可能表现出不同的生物学反应，例如在相似剂量的辐射下对放射治疗的急性和低反应。一些报告表明，与右撇子相比，乳腺癌、包括自身免疫性疾病（如狼疮）在内的免疫性疾病、重症肌无力，甚至过敏发生率在左撇子中更为频繁。本研究的主要目的是通过细胞遗传学检测确定左撇子乳腺癌女性与右撇子女性之间的辐射敏感性。采集 30 名乳腺癌女性（10 名左撇子和 20 名右撇子）的外周静脉血样（10ml），分为两个相同的部分。一部分暴露于 2Gy Co-60 伽马射线，第二部分作为未暴露对照。在标准培养基中培养淋巴细胞，并进行细胞分裂阻断以在双核细胞中计数微核。每个样本中 1000 个细胞的微核频率被认为是辐射敏感性的比率，并通过适当的统计分析比较左撇子和右撇子乳腺癌女性之间的差异。结果表明，左撇子的辐射敏感性指数高于右撇子，也意味着暴露组左撇子的 MN 频率比右撇子升高。似乎左撇子乳腺癌女性比右撇子更敏感。我们实验室正在对右撇子和左撇子健康人进行更多的研究。
