Department of Thoracic Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, PR China.
Eur J Cardiothorac Surg. 2012 Mar;41(3):e7-11. doi: 10.1093/ejcts/ezr240. Epub 2011 Dec 29.
OBJECTIVES; The demographic and clinicopathologic factors associated with 5-year survivors have not been well documented in oesophageal squamous cell carcinoma (OSCC). We evaluated factors predictive of actual 5-year survival in the present research.
We analysed 1241 patients underwent oesophagectomy for invasive OSCC retrospectively. The demographic and clinicopathologic characteristics were compared between patients who were alive >5 years after oesophagectomy and patients who died within 5 years of oesophagectomy.
Univariate analysis showed significant differences between the two groups regarding 11 different factors. Further analysis by logistic regression showed that eight factors were identified as independent predictors of actual 5-year survival.
The independent positive predictors for actual 5-year survival are younger patients, female gender, absence of weight loss, R0 resection, lower pathological T stage, lower pathological N stage, higher histologic grade and more resected lymph nodes.
尚未充分记录与食管鳞癌（OSCC）5 年生存者相关的人口统计学和临床病理学因素。本研究旨在评估与实际 5 年生存相关的预测因素。
我们回顾性分析了 1241 例接受手术治疗的浸润性 OSCC 患者。比较了手术后 5 年以上存活的患者与手术后 5 年内死亡的患者的人口统计学和临床病理学特征。
单因素分析显示两组 11 个不同因素存在显著差异。进一步的 logistic 回归分析显示，有 8 个因素被确定为实际 5 年生存的独立预测因素。
实际 5 年生存的独立正预测因子是年轻患者、女性、无体重减轻、R0 切除、较低的病理 T 分期、较低的病理 N 分期、较高的组织学分级和更多切除的淋巴结。
