• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
An association study of the COL1A1 gene and high myopia in a Han Chinese population.汉族人群中COL1A1基因与高度近视的关联研究。
Mol Vis. 2011;17:3379-83. Epub 2011 Dec 24.
2
Absence of association between COL1A1 polymorphisms and high myopia in the Japanese population.日本人群中COL1A1基因多态性与高度近视之间不存在关联。
Invest Ophthalmol Vis Sci. 2009 Feb;50(2):544-50. doi: 10.1167/iovs.08-2425. Epub 2008 Oct 3.
3
The COL1A1 gene and high myopia susceptibility in Japanese.日本人群中COL1A1基因与高度近视易感性
Hum Genet. 2007 Sep;122(2):151-7. doi: 10.1007/s00439-007-0388-1. Epub 2007 Jun 8.
4
Systematic assessment of the tagging polymorphisms of the COL1A1 gene for high myopia.高度近视相关COL1A1基因标签单核苷酸多态性的系统评估
J Hum Genet. 2007;52(4):374-377. doi: 10.1007/s10038-007-0117-6. Epub 2007 Feb 2.
5
Replication study of significant single nucleotide polymorphisms associated with myopia from two genome-wide association studies.两项全基因组关联研究中与近视相关的显著单核苷酸多态性的重复研究。
Mol Vis. 2011;17:3290-9. Epub 2011 Dec 16.
6
IGF-1 gene polymorphisms in Polish families with high-grade myopia.波兰高度近视家族中的胰岛素样生长因子-1（IGF-1）基因多态性
Mol Vis. 2011;17:2428-39. Epub 2011 Sep 21.
7
High myopia is not associated with single nucleotide polymorphisms in the COL2A1 gene in the Chinese population.高度近视与中国人 COL2A1 基因中的单核苷酸多态性无关。
Mol Med Rep. 2012 Jan;5(1):133-7. doi: 10.3892/mmr.2011.626. Epub 2011 Oct 11.
8
Investigating the relationship between UMODL1 gene polymorphisms and high myopia: a case-control study in Chinese.探讨 UMODL1 基因多态性与高度近视的关系：一项中国的病例对照研究。
BMC Med Genet. 2012 Aug 2;13:64. doi: 10.1186/1471-2350-13-64.
9
Evaluation of BLID and LOC399959 as candidate genes for high myopia in the Chinese Han population.评估BLID和LOC399959作为中国汉族人群高度近视候选基因的情况。
Mol Vis. 2010 Oct 2;16:1920-7.
10
A DNA pooling-based case-control study of myopia candidate genes COL11A1, COL18A1, FBN1, and PLOD1 in a Chinese population.在中国人群中基于DNA池的近视候选基因COL11A1、COL18A1、FBN1和PLOD1的病例对照研究。
Mol Vis. 2011 Mar 26;17:810-21.

引用本文的文献

1
Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children.PCDHA 基因簇中 DNA 甲基化水平降低可作为儿童早发性高度近视的危险因素。
Invest Ophthalmol Vis Sci. 2022 Aug 2;63(9):31. doi: 10.1167/iovs.63.9.31.
2
Genetic Basis of Primary Angle Closure Glaucoma: The Role of Collagens and Extracellular Matrix.原发性闭角型青光眼的遗传基础：胶原蛋白和细胞外基质的作用
J Ophthalmic Vis Res. 2020 Feb 2;15(1):1-3. doi: 10.18502/jovr.v15i1.5930. eCollection 2020 Jan-Mar.
3
Insight into the molecular genetics of myopia.近视分子遗传学的见解。
Mol Vis. 2017 Dec 31;23:1048-1080. eCollection 2017.
4
Evaluation of 10 AMD Associated Polymorphisms as a Cause of Choroidal Neovascularization in Highly Myopic Eyes.评估10种与年龄相关性黄斑变性相关的多态性作为高度近视眼中脉络膜新生血管形成原因的研究。
PLoS One. 2016 Sep 19;11(9):e0162296. doi: 10.1371/journal.pone.0162296. eCollection 2016.
5
Genetic association of COL1A1 polymorphisms with high myopia in Asian population: a Meta-analysis.亚洲人群中COL1A1基因多态性与高度近视的遗传关联：一项Meta分析。
Int J Ophthalmol. 2016 Aug 18;9(8):1187-93. doi: 10.18240/ijo.2016.08.16. eCollection 2016.
6
Association of COL1A1 polymorphism with high myopia: a Meta-analysis.COL1A1基因多态性与高度近视的关联：一项Meta分析。
Int J Ophthalmol. 2016 Apr 18;9(4):604-9. doi: 10.18240/ijo.2016.04.22. eCollection 2016.
7
Polymorphism in the RASGRF1 gene with high myopia: A meta-analysis.RASGRF1基因多态性与高度近视：一项荟萃分析。
Mol Vis. 2015 Nov 14;21:1272-80. eCollection 2015.
8
The genetic mechanisms of primary angle closure glaucoma.原发性闭角型青光眼的遗传机制。
Eye (Lond). 2015 Oct;29(10):1251-9. doi: 10.1038/eye.2015.124. Epub 2015 Jul 24.
9
Association between COL1A1 polymorphisms and high myopia: a meta-analysis.COL1A1基因多态性与高度近视的关联：一项荟萃分析。
Int J Clin Exp Med. 2015 Apr 15;8(4):5862-8. eCollection 2015.
10
Genetic analysis of axial length genes in high grade myopia from Indian population.印度人群高度近视中眼轴长度基因的遗传分析。
Meta Gene. 2014 Feb 15;2:164-75. doi: 10.1016/j.mgene.2014.01.004. eCollection 2014 Dec.

本文引用的文献

1
Exome sequencing identifies ZNF644 mutations in high myopia.外显子组测序发现高度近视中 ZNF644 突变。
PLoS Genet. 2011 Jun;7(6):e1002084. doi: 10.1371/journal.pgen.1002084. Epub 2011 Jun 9.
2
Genetic variants at 13q12.12 are associated with high myopia in the Han Chinese population.13q12.12 上的遗传变异与汉族人群的高度近视有关。
Am J Hum Genet. 2011 Jun 10;88(6):805-813. doi: 10.1016/j.ajhg.2011.04.022. Epub 2011 Jun 6.
3
Role of bone morphogenetic proteins in form-deprivation myopia sclera.骨形态发生蛋白在形觉剥夺性近视巩膜中的作用。
Mol Vis. 2011 Mar 8;17:647-57.
4
Mutation characteristics in type I collagen genes in Chinese patients with osteogenesis imperfecta.中国成骨不全患者I型胶原基因的突变特征
Genet Mol Res. 2011 Feb 8;10(1):177-85. doi: 10.4238/vol10-1gmr984.
5
Prevalence and risk factors for refractive errors in Indians: the Singapore Indian Eye Study (SINDI).印度人屈光不正的患病率和危险因素：新加坡印度眼研究 (SINDI)。
Invest Ophthalmol Vis Sci. 2011 May 16;52(6):3166-73. doi: 10.1167/iovs.10-6210.
6
Perspective: how might emmetropization and genetic factors produce myopia in normal eyes?观点：正视化和遗传因素如何在正常眼睛中导致近视？
Optom Vis Sci. 2011 Mar;88(3):E365-72. doi: 10.1097/OPX.0b013e31820b053d.
7
Population-based estimate of the sibling recurrence risk ratio for rhegmatogenous retinal detachment.基于人群的孔源性视网膜脱离同胞复发风险比的估计。
Invest Ophthalmol Vis Sci. 2011 Apr 20;52(5):2551-5. doi: 10.1167/iovs.10-6375.
8
Shared genetic determinants of axial length and height in children: the Guangzhou twin eye study.儿童眼轴长度与身高的共同遗传决定因素：广州双胞胎眼研究。
Arch Ophthalmol. 2011 Jan;129(1):63-8. doi: 10.1001/archophthalmol.2010.323.
9
Nature and nurture: the complex genetics of myopia and refractive error.先天与后天：近视与屈光不正的复杂遗传学。
Clin Genet. 2011 Apr;79(4):301-20. doi: 10.1111/j.1399-0004.2010.01592.x. Epub 2010 Dec 13.
10
Identification of a locus for autosomal dominant high myopia on chromosome 5p13.3-p15.1 in a Chinese family.在中国一个家族中5号染色体p13.3-p15.1区域常染色体显性高度近视位点的鉴定。
Mol Vis. 2010 Oct 12;16:2043-54.

汉族人群中COL1A1基因与高度近视的关联研究。

An association study of the COL1A1 gene and high myopia in a Han Chinese population.

作者信息

Zhang Dingding, Shi Yi, Gong Bo, He Fei, Lu Fang, Lin He, Wu Zhengzheng, Cheng Jing, Chen Bin, Liao Shihuang, Ma Shi, Hu Jianbin, Yang Zhenglin

机构信息

Sichuan Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Sichuan, China.

出版信息

Mol Vis. 2011;17:3379-83. Epub 2011 Dec 24.

PMID:22219633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3247168/
Abstract

PURPOSE

Single nucleotide polymorphisms (SNPs) in the collagen type I (COL1A1) gene have been shown to be significantly associated with high myopia in a Japanese population. This present study was conducted to investigate whether COL1A1 is associated with high myopia in a Han Chinese population.

METHODS

High myopia is defined by a spherical equivalent of less than or equal to -6.00 diopter sphere and an axial length longer than or equal to 26.0 mm in the affected eye. We genotyped rs2075555 and rs2269336 SNPs in COL1A1 in a Ha n Chinese group composed of 697 high myopia patients and 762 normal controls.

RESULTS

Neither of the two SNPs showed significant association with high myopia (p(allelic)=0.252 for rs2075555, and p(allelic)=0.699 for rs2269336).

CONCLUSIONS

Our study revealed that SNPs in COL1A1 are not significantly associated with high myopia in the Han Chinese population.

摘要

目的

在日本人群中，I型胶原蛋白（COL1A1）基因中的单核苷酸多态性（SNP）已被证明与高度近视显著相关。本研究旨在调查COL1A1基因是否与汉族人群中的高度近视相关。

方法

高度近视定义为患眼等效球镜小于或等于-6.00屈光度且眼轴长度大于或等于26.0毫米。我们对由697例高度近视患者和762例正常对照组成的汉族人群中的COL1A1基因rs2075555和rs2269336单核苷酸多态性进行了基因分型。

结果

两个单核苷酸多态性均未显示与高度近视有显著关联（rs2075555的p（等位基因）=0.252，rs2269336的p（等位基因）=0.699）。

结论

我们的研究表明，COL1A1基因中的单核苷酸多态性与汉族人群中的高度近视无显著关联。