The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
Department of Materials Science and Engineering, The Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 6997801, Israel.
Int J Mol Sci. 2023 Jun 19;24(12):10330. doi: 10.3390/ijms241210330.
Minimalistic peptide- and metabolite-based supramolecular hydrogels have great potential relative to traditional polymeric hydrogels in various biomedical and technological applications. Advantages such as remarkable biodegradability, high water content, favorable mechanical properties, biocompatibility, self-healing, synthetic feasibility, low cost, easy design, biological function, remarkable injectability, and multi-responsiveness to external stimuli make supramolecular hydrogels promising candidates for drug delivery, tissue engineering, tissue regeneration, and wound healing. Non-covalent interactions such as hydrogen bonding, hydrophobic interactions, electrostatic interactions, and π-π stacking interactions play key roles in the formation of peptide- and metabolite-containing low-molecular-weight hydrogels. Peptide- and metabolite-based hydrogels display shear-thinning and immediate recovery behavior due to the involvement of weak non-covalent interactions, making them supreme models for the delivery of drug molecules. In the areas of regenerative medicine, tissue engineering, pre-clinical evaluation, and numerous other biomedical applications, peptide- and metabolite-based hydrogelators with rationally designed architectures have intriguing uses. In this review, we summarize the recent advancements in the field of peptide- and metabolite-based hydrogels, including their modifications using a minimalistic building-blocks approach for various applications.
基于最小肽和代谢物的超分子水凝胶在各种生物医学和技术应用中相对于传统的聚合物水凝胶具有巨大的潜力。与传统聚合物水凝胶相比，超分子水凝胶具有显著的生物降解性、高含水量、良好的机械性能、生物相容性、自修复性、合成可行性、低成本、易于设计、生物功能、显著的可注射性和对外界刺激的多响应性等优点，使其成为药物输送、组织工程、组织再生和伤口愈合的候选材料。氢键、疏水相互作用、静电相互作用和π-π堆积相互作用等非共价相互作用在含有低分子质量水凝胶的肽和代谢物的形成中起着关键作用。基于肽和代谢物的水凝胶由于涉及弱非共价相互作用，表现出剪切变稀和立即恢复的行为，使其成为药物分子输送的理想模型。在再生医学、组织工程、临床前评估和许多其他生物医学应用领域，具有合理设计结构的基于肽和代谢物的水凝胶具有有趣的用途。在本文中，我们总结了基于最小肽和代谢物的水凝胶领域的最新进展，包括使用最小化构建基块方法对其进行的各种应用的修饰。
