Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC 27104, USA.
Am J Clin Dermatol. 2012 Apr 1;13(2):125-8. doi: 10.2165/11594060-000000000-00000.
Trigeminal trophic syndrome (TTS) is the historic name for neuropathic self-induced facial ulceration from abnormal sensory symptoms leading to uncontrolled scratching. Anatomic co-localization of sensory loss (numbness) plus neuropathic itch and pain permits painless scratching. If the itch is severe, some patients will scratch to the point of causing self-injury. Patients may be unaware or may conceal the fact that their lesions are self-induced and thus the diagnosis presents a clinical challenge. Many cases remain undiagnosed, leading to unnecessary and ineffective tests, procedures, and prescribing. We document a patient with a central cause of TTS - multiple cerebral vascular accidents - and summarize the presentation, pathogenesis, and treatment options.
三叉神经营养综合征（TTS）是一种历史悠久的疾病名称，其特征为异常感觉症状导致的自发性面部溃疡，进而引发无法控制的搔抓。感觉缺失（麻木）加上神经病理性瘙痒和疼痛的解剖学共存使得搔抓无痛感。如果瘙痒严重，一些患者会搔抓到造成自身伤害的程度。患者可能没有意识到，或者隐瞒了病变是自我诱导的事实，因此诊断具有一定的临床挑战性。许多病例未得到诊断，导致不必要和无效的检查、程序和处方。我们记录了一例 TTS 的中枢性病因——多发性脑梗死，并总结了其临床表现、发病机制和治疗选择。
