Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
J Adv Nurs. 2012 Sep;68(9):2103-12. doi: 10.1111/j.1365-2648.2011.05916.x. Epub 2012 Jan 3.
To describe the development of a systematic review protocol that maps the evidence relating to drug manipulations conducted to obtain the required dose. This process included defining a search strategy and methods to assess the quality and to synthesize the evidence retrieved.
Economic constraints mean that marketed formulations may not meet the needs of all patients. Consequently, it is sometimes necessary to manipulate marketed products with the aim of obtaining the required dose. Most clinical practice appears to be guided by ad hoc approaches and informal literature reviews.
This systematic review protocol has been designed to identify the evidence available on drug manipulation. The review aims to identify what evidence is available and where the gaps appear in the current evidence. This report describes the challenges of developing a systematic review in an area that potentially involves many drugs and considers outcomes other than effectiveness. In particular, searches required the use of non-specific terms and the iterative development of a complex search strategy. The development of quality assessment criteria is also described. Funding commenced in April 2009.
The systematic review described here will capture a broad selection of research about drug manipulations and may also be of interest to those conducting reviews in broad remit subject areas that are not easy to define using accepted terminology.
描述一个系统综述方案的制定过程，该方案旨在绘制与为获得所需剂量而进行的药物操作相关的证据。这一过程包括定义搜索策略和方法，以评估检索到的证据的质量并对其进行综合。
经济限制意味着上市制剂可能无法满足所有患者的需求。因此，有时有必要对上市产品进行操作，以获得所需的剂量。大多数临床实践似乎都是基于临时方法和非正式文献综述。
本系统综述方案旨在确定现有的药物操作证据。该综述旨在确定现有证据的情况，并确定当前证据中的空白点。本报告描述了在一个可能涉及多种药物的领域制定系统综述所面临的挑战，并考虑了有效性以外的其他结果。特别是，搜索需要使用非特定术语，并迭代开发复杂的搜索策略。质量评估标准的制定也将进行描述。资金于 2009 年 4 月开始。
这里描述的系统综述将涵盖广泛的关于药物操作的研究，对于那些在不易使用公认术语定义的广泛主题领域进行综述的人来说，也可能具有一定的参考价值。
