血清 25-羟维生素 D 与哮喘患者肺炎球菌抗体水平升高有关。
Serum 25-hydroxyvitamin D is associated with enhanced pneumococcal antibody levels in individuals with asthma.
机构信息
Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
出版信息
Allergy Asthma Proc. 2011 Nov-Dec;32(6):445-52. doi: 10.2500/aap.2011.32.3494.
Recent studies suggest that vitamin D modulates innate immunity and reduces the risk of microbial infections. Little is known about the role of vitamin D in antipneumococcal immunity in individuals with asthma. We determined the correlation between serum 25-hydroxyvitamin D (25[OH]D) levels and pneumococcal antibody levels in individuals with asthma, atopic dermatitis, or allergic rhinitis, and atopic sensitization status. A cross-sectional study was conducted for 21 subjects with asthma and 23 subjects without asthma. Pearson's correlation coefficient between serum 25(OH)D concentrations and the number of positive serotype-specific antibody levels was calculated among individuals with and without asthma, atopic dermatitis, and/or allergic rhinitis and atopic sensitization status. The overall correlation between serum 25(OH)D concentrations and positive pneumococcal antibody levels in all subjects regardless of asthma was not significant (r = -0.14; p = 0.38). Stratified analysis results showed that there was a positive correlation between serum 25(OH)D concentrations and positive pneumococcal antibody levels in asthmatic patients (r = 0.45; p < 0.05) and an inverse correlation was observed in nonasthmatic patients (r = -0.53; p < 0.05). These trends were similar for subjects with and without atopic dermatitis and/or allergic rhinitis (r = 0.58 and p = 0.008 versus r = -0.63 and p = 0.001). Despite similar trends in the correlation between serum 25(OH)D and pneumococcal antibody concentrations among those with and without atopic sensitization status (r = 0.27 and p = 0.19 versus r = -0.41 and p = 0.08), they did not reach statistical significance. The 25(OH)D may enhance humoral immunity against Streptococcus pneumonia in subjects with atopic conditions but not without atopic conditions. Atopic conditions may have an important effect modifier in the relationship between serum 25(OH)D concentrations and immune function.
最近的研究表明，维生素 D 可以调节先天免疫，降低微生物感染的风险。关于维生素 D 在哮喘患者抗肺炎球菌免疫中的作用知之甚少。我们确定了哮喘、特应性皮炎、过敏性鼻炎患者以及特应性致敏状态的血清 25-羟维生素 D（25[OH]D）水平与肺炎球菌抗体水平之间的相关性。对 21 例哮喘患者和 23 例非哮喘患者进行了横断面研究。计算了哮喘患者和非哮喘患者、特应性皮炎患者和/或过敏性鼻炎患者以及特应性致敏状态之间血清 25（OH）D 浓度与阳性血清型特异性抗体水平之间的 Pearson 相关系数。无论哮喘与否，所有受试者的血清 25（OH）D 浓度与阳性肺炎球菌抗体水平之间的总体相关性均不显著（r = -0.14；p = 0.38）。分层分析结果表明，在哮喘患者中，血清 25（OH）D 浓度与阳性肺炎球菌抗体水平之间呈正相关（r = 0.45；p <0.05），而非哮喘患者呈负相关（r = -0.53；p <0.05）。在患有和不患有特应性皮炎和/或过敏性鼻炎的患者中观察到类似的趋势（r = 0.58 和 p = 0.008 与 r = -0.63 和 p = 0.001）。尽管在有和没有特应性致敏状态的患者中，血清 25（OH）D 与肺炎球菌抗体浓度之间的相关性存在相似的趋势（r = 0.27 和 p = 0.19 与 r = -0.41 和 p = 0.08），但它们没有达到统计学意义。25（OH）D 可能增强特应性患者对肺炎链球菌的体液免疫，但对非特应性患者则不然。特应性状态可能是血清 25（OH）D 浓度与免疫功能之间关系的重要效应修饰因子。
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