Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Allergy Asthma Proc. 2013 Jul-Aug;34(4):370-377. doi: 10.2500/aap.2013.34.3656.
Serum 25-hydroxyvitamin D (25[OH]D) concentrations are positively associated with pneumococcal antibody titers (PATs) in subjects with atopy or asthma. Little is known about the association of serum 25(OH)D concentrations and the waning of PATs over time in subjects with or without atopy. This study was designed to determine whether serum 25(OH)D concentrations are associated with waning of PATs and if such relationship is modified by atopic conditions. The study was designed as a prospective cohort study, which followed 20 asthmatic patients and 19 individuals without asthma for an average of 12 months. We measured PATs and serum 25(OH)D concentrations at baseline and at a subsequent follow-up visit. Asthma was ascertained by predetermined criteria. The association between serum 25(OH)D concentrations and PATs was determined by Pearson's correlation coefficient and a least square model. Of the 39 children and adults, 21(53%) were male subjects, all were white, and 6 (15%) were children. There was an overall negative correlation between serum 25(OH)D concentrations and the decrease of PATs during follow-up (r = -0.47; p = 0.004), suggesting that higher 25(OH)D concentrations were associated with a reduction in waning of PATs over time. Controlling for follow-up duration and pneumococcal colonization, these trends were significant among asthmatic patients but not in individuals without asthma. Similar trends were observed for individuals with or without other atopic conditions. Serum 25(OH)D concentrations are inversely associated with the waning of PATs over time, especially individuals with asthma and other atopy conditions. These study findings deserve further investigation.
血清 25-羟维生素 D（25[OH]D）浓度与特应性或哮喘患者的肺炎球菌抗体滴度（PAT）呈正相关。特应性或哮喘患者血清 25（OH）D 浓度与 PAT 随时间衰减的相关性知之甚少。本研究旨在确定血清 25（OH）D 浓度是否与 PAT 衰减相关，以及这种关系是否受特应性条件的影响。该研究设计为前瞻性队列研究，对 20 名哮喘患者和 19 名非哮喘个体进行了平均 12 个月的随访。我们在基线和随后的随访中测量了 PAT 和血清 25（OH）D 浓度。哮喘通过预定标准确定。通过 Pearson 相关系数和最小二乘模型确定血清 25（OH）D 浓度与 PAT 之间的关系。在 39 名儿童和成年人中，21 名（53%）为男性，均为白人，6 名（15%）为儿童。在随访过程中，血清 25（OH）D 浓度与 PAT 下降之间存在总体负相关（r = -0.47；p = 0.004），表明较高的 25（OH）D 浓度与 PAT 随时间衰减减少有关。在控制随访时间和肺炎球菌定植的情况下，这些趋势在哮喘患者中具有统计学意义，但在非哮喘患者中则没有。在有或没有其他特应性条件的个体中也观察到了类似的趋势。血清 25（OH）D 浓度与 PAT 随时间衰减呈负相关，尤其是哮喘和其他特应性条件患者。这些研究结果值得进一步研究。
